Chitosan oligosaccharide

Chitosan Oligosaccharide Powder 95% | Premium Water-Soluble Supplement Ingredient with Multi-Target Bioactivity

Xi'an Jiayuan Bio-tech Co., Ltd., founded in 2002 with a registered capital of RMB 30 million, it is a high-tech company specialising in the production of Chitosan oligosaccharide powder with 95% purity. Our product has the following characteristics: molecular weight of 800-1000 Da, degree of deacetylation > 93%, high water solubility up to 50 mg/mL. We produce on two GMP standard manufacturing lines that are ISO9001 certified and provide batch-to-batch consistency for worldwide nutraceutical, cosmetic and agricultural applications. We sell natural products that are good enough for businesses. Our products are tested thoroughly by 30 technical staff and come with full quality documentation.

What Is Chitosan Oligosaccharide?

The product (COS) is a low-molecular-weight unique oligomer prepared by enzymatic hydrolysis of chitosan obtained from deep-sea crab shells. Unlike conventional chitosan, which needs acidic conditions to dissolve, this water soluble molecule is 100% soluble at neutral pH.

The molecular framework is composed of β-(1,4) connected D-glucosamine units. It addresses the major pain points of traditional chitin derivatives (poor bioavailability and formulation incompatibility) with a molecular weight of less than 3,000 Daltons.

This physiochemical benefit allows for easy incorporation into liquid supplements, topical formulations and agricultural sprays without precipitation or clogging of nozzles. COS is cationic, which promotes cellular contact and absorption efficiency.

Functions

The product has been shown by scientific study and industrial application to have multi-target biological activity.

Antioxidant and Anti-inflammatory Effects: It stimulates AMPK pathways and inhibits NF-κB and MAPK inflammatory signalling. The study found a substantial drop in pro-inflammatory cytokines including IL-4, IL-13, and TNF-α. You will see lower levels of oxidative stress indicators (MDA) and an upregulation of antioxidant enzyme activity (GSH-Px, SOD).

Prebiotic & Gut Health Support: Non-plant derived prebiotic, positively influences gut microbiota composition. Supplementation in the diet enhances intestinal morphology by raising villus height and villus : crypt ratio. Digestive enzyme activity increases, especially trypsin in the duodenum, which ensures efficient food absorption.

Immunomodulatory properties: The cationic structure interacts with the cell membranes to enhance the innate immunity. This makes it a helpful ingredient for immune support and seasonal wellness formulations.

Antimicrobial Activity: Natural antibacterial activity helps to preserve clean-label products. It is active against typical germs and does not include harsh chemical preservatives.

Drug Delivery Enhancement: It is biocompatible and positively charged, and is excellent in coating nanostructured lipid carriers. Better sustained-release profiles and lower cytotoxicity permit the drug loading efficiency of up to 86%.

Application Areas

Advanced Nutraceuticals & Diet Supplement: COS are stable in stomach acid and reach the intestinal system undamaged, which is an advantage to your compositions. It is a high performance prebiotic for metabolic health, blood sugar control and cholesterol management. Its high water solubility facilitates easy formulation into capsules, pills, powders and functional drinks.

Cosmeceuticals & Skin Care: Chitosan oligosaccharide penetrates stratum corneum better than high molecular weight alternatives. It increases fibroblasts proliferation and collagen production in anti-aging serums. It is used in medical grade wound dressings for its tissue healing acceleration capabilities. It will be perfect for moisturising formulas and regenerating cosmetics.

Precision Agriculture: COS as a biostimulant is a suitable tank mix partner that enhances crop defence against nematodes and fungal infections such as Fusarium. It improves nutrient absorption and alleviates abiotic stress associated with drought and salinity via alteration in proline accumulation and enzyme activity.

Animal Nutrition: Supplementation increases growth performance and immunological support in livestock and companion animals. Improved gut health and feed conversion efficiency via prebiotic actions.

Pharmaceutical Applications: Beneficial to your pharmaceutical delivery systems due to biocompatibility and biodegradability. It is an efficient excipient in controlled release formulations.

Quality Assurance

The quality assurance is professional and every batch fulfils rigid international requirements.

Molecular Weight Distribution (MWD) We carry out Gel Permeation Chromatography (GPC) analysis to ensure items are firmly within the oligomer range. The narrow dispersion ensures that each batch has uniform biological activity.

Degree of Deacetylation (DDA): Potentiometric Titration and H-NMR confirmed > 93% DDA to guarantee adequate cationic strength for bioactivity.

Solubility & Turbidity Testing Our 1% aqueous solution is transparent with no precipitate confirming compatibility with liquid formulations. This important test will guaranty that it fits your items perfectly.

Heavy metals analysis: Confirmation of ICP-MS for Pb ≤ 0.5 ppm, As ≤ 0.5 ppm, total heavy metals < 10 ppm for food and feed grade. Following the rules preserves your brand’s reputation.

Microbial Limits Total Plate Count (TPC) < 1,000 CFU/g No Salmonella or E. coli: 0 tolerance Safe for direct consumption applications

Other Parameters : Ash content < 1.0% takes away the worries about demineralisation. Moisture < 8.0% to avoid caking and microbiological development during storage.

Why Choose Us?

Direct Manufacturer Advantage: Factory-direct pricing eliminates intermediary markups. You receive competitive quotes with transparent cost structures and flexible warehouse stocking services.

Technical strength: 30 competent technical professionals, more than 20 years of industry experience since 2002, we can offer dependable R&D assistance and customisation skills.

Quality Infrastructure Two manufacturing lines with GMP standards and skilled laboratories guarantee strict quality control. All parameters are verified prior to shipping.

Global Service Network: We partner with leading logistics companies to deliver on time internationally. Customs clearance help makes international procurement easier for new importers.

Extensive Documentation: Certificates and testing reports enable you to comply with regulations and to enter the market.

Certificates

We are fully certified, having ISO9001, ISO22000, SGS, KOSHER, HALAL, BRC and ORGANIC certificates. Full paperwork is supplied: COA, TDS, MSDS/SDS, stability data, allergen declarations, non-GMO statements and certificates of origin.

Payment & Shipment

We accept flexible payment terms including T/T, L/C, and PayPal. Our global logistics network partners with FedEx, DHL, EMS, UPS, TNT, international airlines, and shipping companies for efficient delivery.

For customers without import experience, we offer customs clearance assistance in Europe and North America. This door-to-door service delivers products directly to your facility, reducing logistics complexity and clearance costs.

Packaging & Transportation

Standard Packing: 1kg/aluminum foil bag, 25kg/fiber drum or customised according to your specifications. All packaging is designed to guarantee product stability throughout shipping and storage.

We fine-tune your inventory management to lower your procurement expenditures and transportation cost. You may buy many items in lesser order amounts which makes the supply chain more efficient and avoids paying for logistics several times.

After-sales Service

Our technical team provides formulation guidance and compatibility consultation. We offer free samples for internal evaluation (shipping costs covered by customer). MOQ is flexible: starting from 1kg for trial orders.

Batch-to-batch consistency is guaranteed through strict quality protocols. Should any quality issues arise, we respond within 24 hours with solutions including replacement or refund.

Exhibitions

We participate in major international trade shows including Supply Side West, Vitafoods Europe, CPHI Worldwide, and FIC China. These platforms allow us to showcase innovations and connect with industry professionals globally.

FAQ

Q: What is the difference between the product powder and chitosan? Why does the product work better in applications?

A:Chitosan, a deacetylated derivative of chitin, is only soluble in dilute acids and weighs hundreds of thousands to millions of Daltons. This poor water solubility limits use. A low molecular weight oligomer (800–1000 Da) with >93% deacetylation and 50 mg/mL water solubility is produced. Its low molecular weight and cationic nature make it simpler to absorb and more biologically active, making it popular in functional foods, supplements, cosmetics, and animal nutrition.

Q：What is the major biological activity of the product powder? How does it work? 

A：COS exhibits antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory activities. It promotes AMPK pathways, but blocks inflammatory signalling via NF-?B and MAPK. It inhibits pro-inflammatory cytokines (IL-4, IL-13, TNF-α) in allergy models, enhances antioxidant enzymes (GSH-Px, SOD), and lowers oxidative stress indicators (MDA). These numerous exercises aid joint health, immunological function, gastrointestinal health and skin care applications.

Q: What is the solubility profile of the powder form of the product and what formulation considerations should be taken?

A: Transparent solutions may be made from 50 mg/mL powder in water. Blends well with probiotics, prebiotics, vitamins, minerals, and plant extracts. Be careful with pH—COS is stable around pH 3-9. Avoid powerful oxidizers. It is cationic, thus verify compatibility with anionic polysaccharides and colloids.

Q：What documentation do you provide? What are your minimum order quantity and sample policies?

A：We provide COA, TDS, MSDS/SDS, stability data, allergen declarations, non-GMO statements, and certificates of origin. Kosher and Halal certifications are available. MOQ is flexible starting from 1kg depending on specifications. Free samples are available for internal evaluation, with customers covering shipping costs.

Contact Us

Ready to enhance your formulations with premium Chitosan oligosaccharide powder? Contact our technical team today at sales@jayuanbio.com and sales1@jayuanbio.com  for samples, quotations, and formulation support. We're here to optimize your product development.