Phloretin Powder

High-Purity Phloretin Powder Extract | Apple Polyphenol for Advanced Skincare & Nutraceutical Solutions

Xi'an Jiayuan Bio-tech Co., Ltd. supplies pharmaceutical-grade Phloretin Powder extracted from premium apple peel, delivering exceptional purity with CAS No. 60-82-2 and EN No. 200-488-7 certification. Our plant was established in 2002 with RMB 30 million registered capital. We have two GMP standard manufacturing lines and 30 technical specialists. Our extract has better lipophilicity and bioactivity concerning formulation problems in transdermal absorption and oxidative stability. This dihydrochalcone flavonoid is soluble in methanol, ethanol and acetone and is used as a penetration enhancer and multi-functional active in premium dermatological treatments.

What Is Phloretin Powder?

It is a dihydrochalcone flavonoid of great purity. Chemically it is 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1-one. This aglycone component is more biologically active and has better membrane permeability than its glycoside counterpart phlorizin.

It is a chemical present in the root bark and peel of the apple (Malus pumila). It acts as a natural penetration enhancer by altering the membrane dipole potential of lipid bilayers. This technique enables the transdermal transport of co-formulated actives across the stratum corneum.

Your product is good since it may prevent reactive oxygen species (ROS) and can also stabilize sensitive substances like L-Ascorbic Acid. This extract is better than traditional antioxidants which have problems with oxidative destruction.

COA

产品名称 Product Name	根皮素粉 Phloretin Powder
批号 Lot No	240405	数量 Quantity	800kg
生产日期 Manufacture Date	2024.04.27	有效日期 Expiry Date	2026.04.26
项目 Items	检验标准 Requirements		测定结果 Results
性状 Description	白色粉末 White Powder		符合规定 Conforms
含量 Assay	汁粉		汁粉
粒度 Particle size	80 目 100％pass 80mesh		符合规定 Conforms
灰分 Ash	≤5.0%		3.50%
溶解性 Solubility	98%		99.00%
干燥失重 Loss on drying	≤5.0%		3.40%
重金属 Heavy metal	≤10.0ppm		符合规定 Conforms
砷 Arsenic (As)	≤2.0ppm		符合规定 Conforms
细菌总数 Total Plate Count	≤1000cfu/g		符合规定 Conforms
霉菌及酵母菌 Mold &Yeast	≤100 cfu/g		符合规定 Conforms
大肠杆菌 E. Coli	无 Negative		无 Negative
沙门氏菌 Salmonella species	无 Negative		无 Negative
结论 Conclusion	本产品经检验符合标准 The product conforms to the standard

Functions

Our apple polyphenol extract provides 3 key bioactive mechanisms:

Antioxidant Action: Eliminates free radicals and decreases malondialdehyde (MDA) levels with concurrent preservation of endogenous glutathione systems. The activity protects against inherent and extrinsic aging causes.

Tyrosinase Inhibition: Direct inhibition of the enzyme involved in melanin production. You get noticeable skin lightening without the aggravation that synthetic alternatives like hydroquinone may cause.

Metabolic Regulation: Blocks glucose transporters (GLUT) to assist in sebum management and metabolic balance in topical and oral treatments.

Application Fields

Dermocosmetics: Develop high-end anti-aging serums, brightening treatments and photoprotective solutions. Used synergistically, the extract doubles the photoprotection ability of Vitamin C.

Nutraceuticals: Formulate dietary supplements for metabolic health and antioxidant support with improved oral bioavailability by appropriate encapsulation.

Pharmaceutical Research: Explore therapeutic uses for oxidative stress-related disorders and transdermal drug delivery methods.

Quality Control

We maintain rigorous quality assurance through our ISO9001-certified facilities:

Parameter	Specification
Part Used	Apple Peel
CAS Number	60-82-2
EN Number	200-488-7
Solubility	Methanol, Ethanol, Acetone
pH Stability Range	4.0-5.0 (optimal)
Production Lines	2 GMP-Standard Facilities

Our professional laboratory conducts full-spectrum testing from raw material selection through final inspection for Phloretin Powder. Every batch undergoes strict quality verification before shipment.

Certificates

• ISO9001 Quality Management System Certification (2012)
• SGS Verification
• HALAL Certification
• Private Science and Technology Enterprise of Shaanxi Province (2013)
• High-tech Enterprise of Shaanxi Province (2013)

Payment & Shipment

We support flexible payment terms accommodating various business scales. Our global logistics network includes FedEx, DHL, EMS, UPS, TNT, international airlines, and shipping companies.

For clients without import experience, we provide comprehensive customs clearance assistance in Europe and the United States. Your products arrive directly at your facility with minimized logistics complexity.

Packaging & Transportation

Standard packaging: 25kg/Drum or 1kg/bag. We customize packaging specifications according to your requirements for retail, wholesale, or research applications.

Our optimized logistics solutions reduce shipping expenses and customs clearance costs. You can consolidate multiple products with smaller minimum order quantities, improving supply chain efficiency.

After-sales Service

Our technical team provides formulation guidance to maximize ingredient performance. We offer documentation support for regulatory compliance and assist with stability testing recommendations.

You receive ongoing consultation for application optimization and troubleshooting throughout your product development cycle.

Exhibitions

Attending major international trade shows like Food Ingredients China (FIC), Natural Goods Expo, and SupplySide West is something that we do often. At these events, you will have the opportunity to try out our products for yourself.

Why Choose Us?

Direct Manufacturer Pricing: Factory-direct rates with volume discounts eliminate intermediary costs.

Technical Expertise: Since our 2002 foundation, 30 experienced team members have 20+ years of plant extract knowledge.

Tailored Solutions: Warehouse stocking capabilities and adjustable order amounts to suit your individual procurement requirements.

Quality Assurance: Two GMP manufacturing lines and full certification assure continuous pharmaceutical grade quality.

FAQ 

Q: Why do you say the bioavailability of pure powder is low?

A: Pure phloretin is very hydrophobic and quite crystalline. It cannot migrate successfully over the aqueous stagnant layer of the gut or the lipid-rich stratum corneum without carrier or solvent systems.

Q: How do penetration enhancers like ethoxydiglycol affect bioavailability?

A: They modulate skin lipid fluidity and hence decrease barrier resistance and increase partition coefficient into the viable epidermis.

Q: Micronization to increase bioavailability?

A: Yes. The Noyes-Whitney equation illustrates that a reduction in particle size increases the surface area to volume ratio and, thus, the rate of dissolution.

Q: How does pH affect stability of high bioavailability formulations?

A: Definitely. This chemical is best stable at a slightly acidic pH (4.0-5.0). Deprotonation and fast oxidation at higher pH provide zero biological availability.

Q: How does the bioavailability correlate with the antioxidant capacity in-vivo?

A: Higher bioavailability results in direct increase of intracellular quantities as indicated by lower levels of MDA and preserved glutathione.

Contact Us

Ready to enhance your formulations with premium Phloretin Powder? Contact our technical team at sales@jayuanbio.com and sales1@jayuanbio.com  for specifications, pricing, and samples.