Cucoline Hydrochloride

Cucoline Hydrochloride 98% HPLC | High-Purity Pharmaceutical Intermediate for Anti-Inflammatory Research

Xi'an Jiayuan Bio-tech Co., Ltd. provides high-purity Cucoline Hydrochloride (≥98% by HPLC), a premium alkaloid extracted from Sinomenium acutum rhizomes. The firm was established in 2002 with registered capital RMB 30 million; it has two GMP-standard manufacturing lines and 30 specialised technical specialists. This substance is of pharmaceutical quality and is used in pharmaceutical R & D and biological research. Rigorous quality testing is performed on each batch to verify purity, solubility and structural integrity according to worldwide requirements for NF-κB pathway investigations and autoimmune disease research.

What Is Cucoline Hydrochloride?

The product, also known as Sinomenine Hydrochloride (CAS NO.: 6080-33-7), is a bioactive alkaloid obtained from the dried rhizomes of Sinomenium acutum Rehder et Wilson. Its chemical formula is C19H24ClNO4 and the molecular weight is 365.85. The chemical is a white acicular crystalline powder and with remarkable stability.

The production of the hydrochloride salt greatly increases the water solubility compared to free-base alkaloids. This characteristic is appropriate for laboratory formulations with a need for reproducible dissolving rates. The main mechanism of its action is inhibition of NF-κB activation, which is involved in anti-inflammatory, analgesic and immunomodulatory actions.

We use modern extraction, purification and crystallisation procedures in our manufacturing process. We get our raw ingredients solely from certified botanical sources, guaranteeing traceability from field to lab.

COA of Cucoline Hydrochloride

产品名称 Product Name	盐酸青藤碱 Cucoline Hydrochloride
批号 Lot No	240410		数量 Quantity	500kg
生产日期 Manufacture Date	2024.05.12		有效日期 Expiry Date	2026.05.11
提取来源 Extract Source	SinomeniumAcutumRehderettWilson		原产地 Origin of Herb	China
提取部位 Used Part	根 Root		使用溶剂 Solvents	水&乙醇 Water &E thanol
检验依据 Ref standard	According with the enterprise standard
项目 Items	检验标准 Requirements			测定结果 Results	检验方法 Method
含量 Assay	≥98.0%			98.42%	HPLC
外观 Appearance	白色针状结晶粉末 White acicular crystalline powder			符合规定 Conforms	Organoleptic
味道 Taste	特有的 Characteristic			符合规定 Conforms	Organoleptic
干燥失重 Loss on drying	≤5.0%			4.31%	5g/100℃/2.5hrs
灰分 Ash content	≤5.0%			3.96%	2g/525℃/3hrs
粒度 Particle size	80目筛网通过率95% 95% pass 80 mesh			符合规定 Conforms	80 mesh screen
铅 Lead(Pb)	≤1ppm			符合规定 Conforms	Atomic Absorption
镉 Cadmium(Cd)	≤1ppm			符合规定 Conforms	Atomic Absorption
汞 Mercury(Hg)	≤0.1ppm			符合规定 Conforms	Atomic Absorption
砷 Arsenic (As)	≤1ppm			符合规定 Conforms	Atomic Absorption
溶剂残留 Ethanol	≤5000ppm			1136ppm	GC
细菌总数 Total Plate Count	≤5000cfu/g			符合规定 Conforms	CP2015
霉菌及酵母菌 Mold &Yeast	≤100 cfu/g			符合规定 Conforms	CP2015
大肠杆菌 E. Coli	不得检出 Negative			未检出 Not Detected	CP2015
沙门氏菌 Salmonella species	未检出 Non-detected			未检出 Not Detected	CP2015
金黄色葡萄球菌 Staphylococcus aureus	未检出 Non-detected			未检出 Not Detected	CP2015
Non-GMO, Non-Irradiation, Allergen Free
储存条件 Storage Condition:	保存在密闭的容器中，室温控制。 Preserve in tight containers at controlled room temperature .
包装规格 Packing	25kg纸板桶，内双层塑料袋 25kg in drum with double plastic bag inside
结论 Conclusion	本产品经检验符合企业标准 The product conforms to the enterprise standard

Functions

The product provides specific bioactivity through multiple pathways. Its main action is focused on the suppression of NF-κB, a crucial transcription factor that controls inflammation and immunological responses.

Anti Inflammatory Action: Suppresses NF-κB nuclear translocation to diminish pro-inflammatory cytokines production. “This mechanism can be used for research on chronic inflammatory diseases.

Analgesic properties: The chemical affects pathways involved in pain signalling and may be useful for studying pain mechanisms. This is used by researchers to find alternative analgesics with less adverse effects.

Immunomodulation: It modulates the activation and proliferation of immune cells. This function is very significant in the study of autoimmune diseases where balanced immune responses are of utmost significance.

These functional properties make it a valuable reagent for pharmaceutical discovery programmes and cellular biology research.

Application Areas

Our substance is proven pure and reproducible for your research applications:

Pharmaceutical R&D: It is used as an intermediary for the anti-inflammatory and analgesic medication prospects by formulation scientists and medicinal chemists. Its well-characterized structure speeds up lead optimisation operations.

Autoimmune Research – Immunology labs utilise it to study rheumatoid arthritis, lupus and other autoimmune diseases. The molecule is used as a chemical probe to investigate the illness processes .

Cell signalling studies: Used by molecular biologists in NF-κB pathway studies. Its specific action helps to separate complicated signalling pathways in inflammation and apoptosis.

Comparative Pharmacology It is compared with synthetic analogues to determine structure-activity correlations . This application fosters innovation in safer therapeutic leads.

We package products from milligram to gram quantities, accommodating both pilot studies and scaled research programs.

Quality Control

We carry out full quality control at all stages of manufacturing. The first authentication involves botanical identification and screening for pesticide residues of raw materials.

Temperature, pH and solvent ratios are controlled at important control points during extraction and purification. Our crystallisation method provides a constant particle size distribution for consistent solubility.

Purity measurement (≥98%) is done by HPLC . Finished product testing Spectroscopic techniques are used for structural confirmation . Additional testing include moisture content, residual solvents and heavy metals.

Each manufacturing batch is given a unique traceability code. Our laboratory information management system manages data from raw material input to final product release providing complete chain transparency.

Qualification Certificates

Xi'an Jiayuan Bio-tech achieved the ISO9001 Quality Management System Certification (in 2012) for Cucoline Hydrochloride. We are a Shaanxi Province Private Science and Technology Enterprise and Shaanxi Province High-tech Enterprise (2013).

Every batch is provided with a Certificate of Analysis (COA) that details purity, appearance, solubility, moisture and residual solvent content. MSDS (Material Safety Data Sheet) and COO (Certificate of Origin) available upon request.

Payment & Shipment

We primarily accept T/T for international transactions. Alternative payment methods—including L/C, D/P, PayPal, MoneyGram, and Western Union—are available based on order specifics.

Our logistics network includes partnerships with FedEx, DHL, EMS, UPS, and TNT, plus international airlines and shipping companies. For customers in Europe and the United States without import experience, we offer customs clearance support to simplify delivery to your facility.

Standard orders ship within 7–15 business days. Urgent orders can be expedited to 3–5 business days subject to stock availability.

Packaging & Transportation

Products are shipped in light-protected airtight containers to keep them stable throughout transit. We ship at ambient or refrigerated (2-8C) settings based on your preferences.

All packages come with complete export documentation: commercial invoice, packing list, COA, and sanitary certifications. Multi-layer sealing prevents ingress of moisture, thermal insulation prevents temperature sensitive shipments.

We optimise packaging for multi-product orders to save recurrent transport costs and improve your supply chain efficiency.

After-sales Service

Our technical support staff will respond to formulation enquiries, storage assistance and analytical troubleshooting. Should we find any quality inconsistencies we commence enquiry within 24 hours and give resolution alternatives including product replacement.

Qualification testing provided with free samples. We do not sell to people in retail amounts. All sales are business-to-business.

Why Choose Us?

Factory Direct Supply: Cut out the middle man and take advantage of factory direct pricing to find cost efficient alternatives for your procurement budget.

Flexible Order amounts: Standard MOQ is 1 kilogram, however we offer reduced amounts when you buy more goods to optimise your inventory management.

Full Documentation: Complete all regulatory documents (COA, MSDS, certificates) to help prevent customs delays and satisfy your institutional requirements.

Technical skills: Our team of 30 professional and technical people will walk you through the application that best meets your research goals.

Global Logistics Network: We collaborate with the world’s leading courier and freight companies to assure dependable delivery to over 60 countries and customs clearance support in important markets.

FAQ

Q: How do you ensure batch-to-batch quality consistency? What specifications do you follow? Can you provide a complete COA for each batch?

A：We implement strict quality control from raw material to final product, adhering to purity ≥98% (by HPLC). Each batch is accompanied by a complete COA covering purity, appearance, solubility, moisture, and residual solvents to guarantee consistency.

Q: What is the MOQ and lead time? Can you handle urgent orders?

A：Standard MOQ is 1 kg. Regular orders are delivered within 7–15 business days. For urgent orders, we can expedite shipment to 3–5 business days depending on stock availability.

Q: Are there special shipping requirements? Who manages customs clearance?

A：Ship at ambient temperature or refrigerated (2–8°C) if required, protected from light and moisture. We provide full export documentation; import clearance is handled by the buyer's local agent.

Q: What payment terms are accepted?

A：We primarily accept T/T. L/C, D/P, PayPal, MoneyGram, and Western Union are also available upon negotiation.

Q: How should I store the product after receiving it?

A：Store at -20°C in sealed, dry, light-protected containers for shelf life of 12–24 months. Refrigerated storage at 4°C is also acceptable. Once in solution, use within 1 month at 0–4°C and avoid repeated freeze-thaw cycles.

Contact Us

Ready to advance your research with high-purity Cucoline Hydrochloride? Contact our team at sales@jayuanbio.com and sales1@jayuanbio.com for quotations, sample requests, or technical consultations. We're here to support your success.