High-Purity Benfotiamine Powder 98%-102% | Lipid-Soluble Thiamine Derivative for Enhanced Bioavailability
Xi'an Jiayuan Bio-tech Co., Ltd., established in 2002 with a registered capital of RMB 30 million, specializes in producing pharmaceutical-grade Benfotiamine Powder meeting JP standards. We have two GMP certified manufacturing lines and follow high quality standards with ISO9001 certification. We are a company identified by Shaanxi Province as a high-tech firm, providing products with purity of 98%-102% (HPLC test), sulphate content ≤0.01%, and batch consistency assured. We have 30 technical professionals and 80 devoted staff to provide dependable supply solutions. MOQ is from 1kg, free samples may be provided and ready stock is available for fast despatch.
What Is Benfotiamine Powder?
The product (CAS No. 22457-89-2) is a synthetic, lipid-soluble derivative of Vitamin B1 with higher bioavailability than water-soluble thiamine salts. Its chemical formula is C19H23N4O6PS and is open-ring which enhances passive diffusion across the intestinal cell membranes. This unique feature enables it to escape saturation of transport systems, and achieve ~360% better systemic bioavailability compared to thiamine hydrochloride.
Clinical studies show that this substance raises blood thiamine levels by 5 times and tissue levels by 10-40 times. The molecule is effectively metabolised to active Thiamine Pyrophosphate (TPP) in the liver and peripheral organs. Its lipophilic property addresses the crucial absorption bottleneck of conventional B1 supplements.
It is a white crystalline powder, has no taste or odour and provides major benefits in formulation flexibility. Melting point 200-210°C with excellent stability under ambient storage conditions owing to minimal hygroscopicity.
Why Choose Us?
Direct Manufacturer Advantage: Factory-direct pricing eliminates intermediary costs. You receive competitive quotes with transparent cost structures and flexible minimum order quantities supporting efficient procurement planning.
Technical Expertise: With 30 specialized technical personnel, we provide formulation support, stability data, and regulatory guidance. Our R&D capabilities enable custom specifications meeting your unique application requirements.
Quality Assurance: Two GMP production lines and comprehensive certification portfolio ensure consistent product quality. Every batch meets stringent international standards with complete documentation support.
Logistics Excellence: Established networks covering major shipping carriers and customs clearance expertise in key markets simplify your import process. We deliver products directly to your facility regardless of location complexity.
Inventory Flexibility: Ready stock availability enables rapid order fulfillment. Our warehouse stocking services allow you to purchase multiple ingredients in smaller quantities, reducing your inventory carrying costs.
COA
| Product Name | Benfotiamine Powder | ||
| Lot No | 240301 | Quantity | 1000kg |
| Manufacture Date | 2024.04.02 | Expiry Date | 2026.04.01 |
| Ref standard | According with the enterprise standard | ||
| Items | Requirements | Results | |
| Assay | ≥98.0% | 99.60% | |
| Identification | IR spectra shows the similarity between sample and standard | Conforms | |
| The retention time of the major peak corresponds with it of the reference standard | Conforms | ||
| Appearance | Pale-yellow or almost white powder; | White powder | |
| Clarity and color of solution | Colorless to pale -yellow clear solution | Conforms | |
| Color | White | Conforms | |
| Odor | odorless | odorless | |
| Loss on drying | ≤1.5% | 0.60% | |
| Chloride | ≤0.053% | <0.053 | |
| Sulfate | ≤0.011% | <0.011% | |
| Heavy metal | ≤20ppm mg/kg | <20ppm | |
| Related substances | Benzoic acid: ≤0.1% | Conforms | |
| Thiamine: ≤0.1% | Conforms | ||
| Total impurities:≤1.0% | Conforms | ||
| Identification | Must positive | Conforms | |
| Conclusion | The product conforms to the enterprise standard | ||
Functions
|
Parameter |
Specification |
|
Assay (HPLC) |
98.0% - 102.0% |
|
Molecular Weight |
466.45 g/mol |
|
Appearance |
White crystalline powder |
|
Solubility |
Practically insoluble in water; soluble in alkaline solutions |
|
Melting Point |
200-210°C (with decomposition) |
|
Sulfate Content |
≤0.01% |
|
Loss on Drying |
≤0.5% |
Its main mechanism is the activation of the enzyme transketolase, which prevents three key routes of hyperglycemic damage: hexosamine, protein kinase C and production of Advanced Glycation End-products. The action targets oxidative stress and vascular problems associated with metabolic disease.
Its non-hygroscopic qualities make it particularly useful in your formulations to increase shelf-life in complicated nutritional blends. It is chemically inert until metabolised, unlike thiamine mononitrate and such inertness contributes to product stability throughout distribution.
Application areas
Benfotiamine Powder is used in the following industrial segments:
Pharmaceutical Uses: It is widely used in formulations for the therapy of diabetic neuropathy in Japan and Germany where the regulatory environment allows it to be classified as an active pharmaceutical constituent. It is useful in the treatment of nerve damage caused by excessive hyperglycemia.
Nutraceutical Products: This substance is used in premium dietary supplements that aim to boost metabolic health, improve cognitive performance, and optimise energy metabolism. Its absorption profile is exceptional, making it a perfect ingredient in high strength B-complex formulations.
Functional Foods: Its stability and bland character are used in sports nutrition products, energy bars, and fortified drinks. The chemical is stable at processing temperatures and retains its effectiveness beyond the shelf-life of the product.
Clinical Nutrition: Medical nutrition solutions provide bioavailability benefits to individuals with thiamine deficient diseases or who need higher dosage with B1.
Quality Control
Our quality assurance system encompasses comprehensive testing protocols:
Every production batch undergoes HPLC purity verification, residual solvent analysis, heavy metal screening (Pb, As, Cd, Hg), and microbiological testing. We maintain strict specifications for sulfate content, loss on drying, and residue on ignition parameters.
Our laboratory facilities employ advanced analytical equipment including HPLC systems, GC detectors, and spectrophotometers. Each certificate of analysis includes complete identity confirmation, assay results, and impurity profiles.
Raw material traceability systems track every ingredient from qualified suppliers. In-process quality checkpoints monitor critical parameters during crystallization, drying, and milling stages. Final product release requires approval from our QA director after comprehensive documentation review.
Payment & Shipment
We accept multiple payment methods for Benfotiamine Powder including T/T, L/C, Western Union, and PayPal for your convenience. Standard payment terms offer flexibility based on order volume and customer relationship history.
We work with FedEx, DHL, EMS, UPS and TNT for global logistics to make sure of dependable delivery to your destination. We work with reputed shipping companies to provide your ocean freight needs with low prices for big orders.
If you are new to import, we provide full help for customs clearance in Europe and North America. Our logistics staff handles the paperwork, tariff categorisation and delivery scheduling to make the purchase process as seamless as possible for you.
Packing & Delivery Details
Standard packaging is pharmaceutical grade aluminium foil bags (1kg, 5kg) within fibre drums with double polyethylene bag liners. This structure guards against moisture, light and contamination in transportation.
We can supply bespoke packaging options for bulk orders above 25kg to suit your warehousing requirements. All containers are clearly marked with batch numbers, production dates and handling instructions according to international transit rules.
There are temperature-controlled logistics for sensitive locations. Full supply chain visibility is provided with meticulous shipment records and tracking information.
Certificates
Xi'an Jiayuan Bio-tech holds multiple international certifications demonstrating our commitment to quality excellence:
ISO9001 Quality Management System Certification (obtained 2012)
HALAL Certification for products serving Islamic markets
SGS Third-Party Testing Verification
Private Science and Technology Enterprise of Shaanxi Province (2013)
High-tech Enterprise of Shaanxi Province (2013)
After-sales Service
Your satisfaction drives our continuous improvement efforts. We provide technical consultation throughout product integration, offering formulation guidance and stability testing recommendations.
Should you encounter any quality concerns, our responsive customer service team initiates investigation protocols within 24 hours. We have product liability insurance and provide replacement guaranties for proven quality concerns on every order.
Long-term relationships include specialised account management, priority production scheduling and tailored inventory solutions to help reduce your procurement complexity.
Exhibitions
Xi’an Jiayuan Bio-tech often attends international industry shows such as Supply Side West, Vitafoods Europe and CPHI Worldwide. Through these channels we are able to present our new items and connect directly with clients all around the world.
By exhibiting we are showing our industry leadership and dedication to innovation. Come see us at our booth for product sampling, technical conversation and collaboration exploration prospects.
FAQ
Q: Why is the product not dissolving in my water-based formulation?
A: Benfotiamine is fat soluble and not water-soluble. It will not dissolve in water unlike Thiamine HCl. For use in liquid form, it needs emulsification, suspension agents or dissolving in oil phase/lipid carrier.
Q: What is the stability of the product in storage under high humidity compared to Thiamine Mononitrate?
A: The product is much more stable. Thiamine Mononitrate is hygroscopic and susceptible to hydrolysis with moisture. Benfotiamine is a non-hygroscopic and chemically inert molecule until metabolised, which extends shelf-life in complex blends.
Q: Is Benfotiamine converted into active Thiamine in the body?
A: Clinical investigations show that Benfotiamine boosts blood levels of thiamine 5 times and tissue levels 10-40 times compared to equal dosages of water-soluble salts. The open ring shape allows passive transport across cell membranes.
Q: Is the product a Dietary Supplement or Drug?
A: Regulatory status depends on the area. It is regulated as a Dietary Supplement (DSHEA) in the U.S.A. In certain areas, including Japan and Germany, it is typically regulated as a pharmaceutical for treatment of neuropathy. Buyers are subject to local regulatory categorisation.
Q: What are the precise interactions in a premix with other vitamins?
A: Benfotiamine is often non-reactive. It should not, however, be coupled with strong reducing agents or strongly alkaline substances (pH > 8) in liquid solutions, since this may lead to premature ring closure or breakdown prior to consumption.
Contact Us
Ready to enhance your formulations with pharmaceutical-grade Benfotiamine Powder? Contact our technical sales team at sales@jayuanbio.com and sales1@jayuanbio.com for quotations, samples, or application support.
