Griffonia Seed Extract

Griffonia Seed Extract – Premium 5-HTP Natural Supplement Ingredient with Standardized Purity Solutions

Xi'an Jiayuan Bio-tech Co., Ltd., established in 2002 with RMB 30 million registered capital, offers pharmaceutical-grade Griffonia Seed Extract standardized to 98% 5-HTP purity by HPLC. Operating two GMP-compliant production lines and backed by ISO9001, HALAL, and KOSHER certifications, we deliver scalable monthly production at ton-level capacity. Our extract sourced from West African Griffonia simplicifolia seeds provides superior bioavailability compared to synthetic alternatives. With 80 employees including 30 R&D specialists and over 20 years of extraction expertise, we ensure batch-to-batch consistency through rigorous quality protocols—moisture ≤5.0%, heavy metals Pb ≤2 ppm, microbial safety guaranteed.

What Is Griffonia Seed Extract?

The product is a standardised botanical substance obtained from the seeds of the woody climbing shrub Griffonia simplicifolia, which is native to West and Central Africa. This extract is the principal commercial source of 5-Hydroxytryptophan (5-HTP), with natural quantities of 6-14% in raw seeds.

The excerpt sets forth the main problems for the sector. 5-HTP penetrates the blood-brain barrier without the need of transport carriers, overcoming the bioavailability restrictions of L-Tryptophan in mood support preparations. It addresses the increasing need for clean-label, plant-based alternatives to pharmaceutical antidepressants.

For extraction we use ethanol-water methods to standardise active content from 20 to 99% of purity. This guaranties the supply chain stability despite seasonal fluctuations of crops and hence stable raw materials for the production of nutritional supplements.

COA 

Product Name	Griffonia Seed Extract
Items	Standard		Results
Assay	98%		98.6% HPLC
Impurity	≤0.5%		0.2% HPLC
Appearance	White Fine Powder		Conforms
Solubility	10mg per mL in water		Conforms
Particle size	98% through 80 mesh		Conforms
Loss on drying	≤1%		0.1%(USP44)
Residue on Ignition	≤0.3%		0.1%(USP44)
Optical Rotation	’-30.0 º～-35.0º		‘-31.7º(USP44)
Heavy Mental	≤10ppm mg/kg		Conforms
Cadmium(Cd)	≤0.1ppm mg/kg		Conforms
Mercury(Hg)	≤0.1ppm mg/kg		Conforms
Arsenic (As)	≤0.5ppm mg/kg		Conforms
Total Plate Count	≤1,000 CFU/g		CP2020
Mold &Yeast	≤100 CFU/g		CP2020
E. Coli	Negative		Conforms
Salmonella species	Negative		Conforms
Staphylococcus aureus	Negative		Conforms
Conclusion	The product conforms to the Enterprise standard

Functions

5 - HTP is the active ingredient . It is a direct metabolic precursor of serotonin and melatonin , two neurotransmitters that regulate many physiological processes .

Mental Health and Mood Support: Clinical investigations have shown anxiolytic effects at dosages of 10-25 mg/kg in preclinical animals. The extract increased the time spent in light compartments during dark-light behavioural tests suggesting lower anxiety feelings .

Sleep Quality Enhancement: By supporting melatonin synthesis pathways, the extract assists natural sleep cycle regulation without requiring intermediate conversion steps.

Appetite Management: Research confirms dose-dependent reduction in food intake and body weight. This supports traditional applications in satiety-inducing weight management formulas.

Antioxidant Activity: 43 bioactive molecules were identified by HPLC-MS, including 34 phenolic constituents, isomyricitrin, taxifolin and flavonol glucuronides. High radical scavenging capability of hydroalcoholic extracts.

Antimicrobial action: The extract has antiproliferative action on cancer cell lines including HeLa, HepG2 and MCF-7. Antibiotics have been shown to have dose-dependent effects against Staphylococcus aureus.

Areas of Application

The way you formulate your needs will decide the most effective way to use the product:

Supplements: Standardised capsules and tablets For mood support, anxiety alleviation and improved sleep Particle size distribution (80-120 mesh) avoids segregation in complex matrices containing melatonin, GABA or magnesium For high load tablets MCC binders may be used to avoid capping.

Functional Foods & Beverages: Fortified protein blends, health bars, and wellness drinks. Microencapsulation addresses slight bitterness in powdered shake mixes while maintaining rapid release profiles.

Functional Confectionery The production of gummies offers thermal problems at process temperatures of around 120°C. We propose encapsulation with antioxidants like Vitamin C to avoid browning and loss of efficacy throughout shelf life.

Pharmaceutical Intermediates Raw material for 5-HTP based products, meeting pharmaceutical-grade purity criteria.

Recent studies suggest topical preparations for the treatment of vulvovaginal candidiasis and in adjuvant chemotherapy procedures. An extract of Griffonia Seed Extract showed antimetastatic activity in osteosarcoma cell lines without influencing the efficiency of doxorubicin.

Certificates

Our facilities maintain comprehensive certifications ensuring regulatory compliance across global markets:

• ISO9001 Quality Management System
• FSSC22000 Food Safety System
• HALAL Certification
• KOSHER Certification
• HACCP Food Safety Management

Additional certifications available upon request to meet your regional regulatory requirements.

Quality Control

Test Item	Specification
Botanical Source	Griffonia simplicifolia Seeds
Active Content	98% 5-HTP (HPLC)
Appearance	White fine powder
CAS Number	56-69-9
Molecular Formula	C11H12N2O3
Molecular Weight	220.23
Particle Size	80-120 mesh (customizable)
Moisture	≤5.0%
Heavy Metals (Pb)	≤2 ppm
Total Plate Count	≤10,000 CFU/g
Salmonella	Negative
E. coli	Negative
Shelf Life	36 months
Storage	Cool, dry, away from light

Every batch undergoes HPLC verification for 5-HTP content. Third-party testing reports available upon request. Certificate of Analysis provided with each shipment.

Payment & Shipment

Payment Terms: T/T (30% deposit, 70% against B/L), L/C, Western Union, PayPal, DA, DP, Visa, MasterCard, Escrow

Shipping Methods:

• Express Delivery (3-5 days): FedEx, DHL, EMS, UPS, TNT
• Air Freight: International airlines for medium volumes
• Sea Freight: Cost-effective bulk shipments

We provide customs clearance assistance for clients in Europe and North America without import experience. Products can be delivered directly to your facility with reduced logistics complexity.

Packaging & Transportation

Standard Packaging:

• Sample Orders: 1kg aluminum foil bags with inner vacuum seal
• Bulk Orders: 25kg fiber drums with double-layer polyethylene bags
• Custom Packaging: Available based on your specifications

Transportation: Temperature regulated logistics avoid moisture exposure and thermal deterioration during transport. All shipments are appropriately marked according to international hazardous goods rules when applicable.

After-sales Service

Our commitment extends beyond delivery. You receive 24/7 technical support from our team of 30 R&D specialists. We assist with formulation optimization, regulatory documentation, and troubleshooting manufacturing challenges.

Free samples available for testing and validation. Batch reservations supported for long-term supply agreements. Rework policies protect your interests in case of quality discrepancies.

Exhibitions

We participate in major international trade shows including:

• SupplySide West (Las Vegas)
• Vitafoods Europe (Geneva)
• CPHI Worldwide (Frankfurt)

Visit our booth to discuss your specific Griffonia Seed Extract requirements and explore custom formulation opportunities.

Why Choose Us?

Direct Manufacturer Pricing: Factory-direct rates eliminate intermediary costs. Flexible warehouse stocking services reduce your inventory pressure.

Scalable Production: Monthly ton-level capacity with 2-5 working days lead time for standard specifications. ODM/OEM services support your private label initiatives.

Technical Expertise: Over 20 years of extraction experience combined with advanced HPLC analysis capabilities. Our 30 technical personnel provide formulation guidance tailored to your application.

Global Logistics Network: Reliable delivery to more than 60 countries with the help of partnerships with leading carriers and customs clearance assistance.

Quality Assurance: Full traceability on raw materials from West African vendors. Dual GMP manufacturing lines with various quality check points eliminate batch variances.

FAQ

Q：How do you ensure batch-to-batch quality consistency?

A：We implement strict raw material traceability and quality control throughout  production, with HPLC testing for 5-HTP content on every batch. COA provided with each shipment.

Q：What purity grades and quality standards are available?

A：Available in multiple specifications: 20%, 50%, 95%, 98%, and 99% 5-HTP. Certifications include ISO, HACCP, KOSHER, HALAL, and cGMP. Key specifications: moisture ≤5.0%, heavy metals Pb ≤2 ppm, TPC ≤10,000 CFU/g, Salmonella and E. coli negative.

Q：What is your standard lead time?

A：For regular stock items such as standard-grade 5-HTP extract, shipment can be arranged within 2-5 working days after order confirmation.

Q：What packaging and shipping methods are available?

A：Packaging includes 1kg aluminum foil bags for samples and 25kg fiber drums for bulk orders. Custom packaging is available. Shipping options include express delivery (3-5 days), air freight, and sea freight. Payment terms: T/T (30% deposit, 70% against B/L), L/C, Western Union, and PayPal.

Contact Us

Ready to secure your supply of premium Griffonia Seed Extract? Contact our team at sales@jayuanbio.com and sales1@jayuanbio.com  for quotes, samples, or technical consultations. Let's discuss how we can support your formulation goals.