Milk Thistle Extract Powder

High-Purity Milk Thistle Extract Powder | Standardized Silymarin Solutions for Liver Health Applications

Xi'an Jiayuan Bio-tech Co., Ltd. delivers pharmaceutical-grade Milk Thistle Extract Powder with standardized silymarin content reaching ≥90% (USP standard). Our extract is made from quality Silybum marianum seeds and processed via ISO9001 certified GMP manufacturing lines. The composition ratios of silybin A/B (40-65%), silydianin/silychristin (20-45%) and isosilybin A/B (10-20%) are accurate. We have been producing for over 20 years and can produce tonnes per month, servicing nutritional supplement makers, pharmaceutical developers and functional food producers across the world. Each batch is analysed by HPLC, results showing Pb ≤2ppm, moisture ≤5.0% and microbial counts in compliance with pharmacopoeia norms.

What Is Milk Thistle Extract Powder?

The product is a concentrated botanical substance extracted from Silybum marianum seeds using sophisticated extraction and spray drying technologies. The active ingredient group is silymarin, which consists of many flavonolignans: silybin (the most bioactive form), silydianin and silychristin.

The best blending of this light yellow to brownish yellow powder is obtained with a particle size of 80-120 mesh. Our standardised extract has consistent silymarin profiles, as confirmed by UV-Vis and HPLC techniques. The main active component is identified by CAS number 22888-70-6, chemical formula C25H22O10, molecular weight 482.436.

COA of Milk Thistle Extract Powder

Product Name	Milk Thistle Extract Powder
Item	Specification		Result	Test Method
Appearance	Light Brown Powder		Conforms	Visual
Odor	Unique smell		Conforms	Organoleptic
Taste	Unique taste		Conforms	Olfactory
Bulk Density	Slack Density		43.00g/100ml	USP616
	Tight Density		67.00g/100ml	USP616
Particle Size	95%Through 80 Mesh		Conforms	CP2015
Assay	≥40.0%		41.50%	HPLC
Moisture	≤1.0%		0.20%	CP2015 (80 oC, 4 h)
Ash	≤1.0 %		0.60%	CP2015
Total Heavy Metals	<10 ppm		Conforms	CP2015
Aerobic Bacterial Count	≤1,000 CFU/g		Conforms	GB4789.2
Yeast	≤100 CFU/g		Conforms	GB4789.15
Mold	≤100 CFU/g		Conforms	GB4789.15
Escherichia Coli	<3.0MPN/g		Conforms	GB4789.38
Salmonella	Not Detected		Conforms	GB4789.4
Staphlococcus Aureus	Not Detected		Conforms	GB4789.10
Conclusion	The product conforms to the enterprise standard

Core Functions of Silymarin Complex

Hepatoprotective Mechanisms

The silymarin complex offers three scientifically proven approaches to protect the liver. First, antioxidant activity scavenges free radicals and increases the levels of glutathione in hepatocytes. Second, anti-inflammatory activity blocks NF-kB and COX-2 enzymes, lowering inflammatory indicators. Thirdly, membrane stabilisation reduces entry of toxins into liver cells.

Research demonstrates considerable decrease in indicators of ethanol-induced liver impairment including ALT, TNF-α & IL-6 levels. These processes make it a beneficial ingredient in compositions for liver rehabilitation.

Additional Biological Activities

In addition to its liver-protective effects, silymarin has shown promise in managing diabetes by enhancing insulin sensitivity. Cardiovascular advantages include enhancement of endothelial function and lipid profile optimisation. Renal protective effects may be due to lowering of oxidative stress in renal tissues.

Novel studies address anticancer effects linked to cell cycle control and apoptosis triggering in several cell lines. These numerous bioactivities enhance the chances of applications in a wide range of therapeutic areas.

Application Fields

Dietary Supplements Manufacturing

Use in the formulation of hard shell capsules, tablets, softgels, and powder mixes for liver health products. It also assures uniform dosing from one batch of manufacturing to the next. Then, it is combined with phospholipids by the formulators using phytosome technology to boost bioavailability overcoming the inherent weak water solubility.

Pharmaceuticals Development

The extract is used as Active Pharmaceutical Ingredient (API) in prescription and OTC drugs for toxic liver damage caused by alcohol or environmental pollutants. It is for treatment of chronic hepatitis and cirrhosis with rigorous impurity profiles. High silybin content ratios provide uniform pharmacokinetics in medicinal applications.

Functional Food and Beverage

Water-soluble grades might be added to health beverages, fortified teas and functional meals. The heat-stable powder can survive the processing temperatures used in tableting and encapsulation. Liquid formulations are packaged by beverage producers using specialised carriers such as cyclodextrins.

Formulations for cosmetics

Anti-inflammatory and antioxidant qualities that help in the formulation of skin care products. It is included in serums, creams and lotions to protect skin and reduce inflammation. The small mesh size allows for easy incorporation into cosmetic bases.

Animal Nutrition

The extract is used in premium veterinary feed additives for poultry and aquaculture to fight mycotoxicosis due to contaminated feed. It is resilient in high temperature pelleting procedures and efficiently binds toxins in the digestive system.

Certifications & Compliance

Xi'an Jiayuan Bio-tech maintains multiple certifications ensuring regulatory compliance across global markets:

• ISO9001 Quality Management System
• FSSC22000/ISO22000 Food Safety Management
• HALAL and KOSHER certifications
• HACCP Hazard Analysis Critical Control Points

Milk Thistle Extract Powders are of USP (United States Pharmacopoeia) and Chinese Pharmacopoeia standards and may be used for pharmaceutical and nutraceutical purposes. Our facility is GMP certified and audited by a third party on a regular basis.

Quality Control System

Our two manufacturing lines are GMP compliant and work to strict quality standards at all levels. Controlled farms provide botanical authenticity by DNA barcoding when required for raw material procurement.

The essential control points during extraction monitor the residues of solvents, temperature factors and extraction duration. Consistency of the silymarin profile is assured by HPLC testing, with each batch meeting target criteria.

Final products undergo comprehensive testing including:

• Silymarin content verification (UV-Vis and HPLC methods)
• Heavy metal screening (ICP-MS)
• Microbial contamination assessment
• Moisture and ash content analysis
• Particle size distribution testing

Retain samples remain stored for two years, enabling traceability. Each shipment includes a Certificate of Analysis (COA), with third-party reports available upon request.

Payment & Shipment Options

We offer flexible payment term, such as T/T (30% deposit, 70% balance against B/L), L/C at sight, Western Union, Paypal and major credit cards. For current partners we may work out individual payment terms.

Delivery Methods:

• Express delivery (3-5 days) - Fedex, DHL, EMS, UPS, TNT for orders 1-100kg
• Air Freight (5-7 days): Cheap for medium amounts 100-500kg
• Sea Freight (20-35 days) Cost-effective bulk shipping for orders above 500kg.

We give customs clearance support to clients in Europe and the United States who have no prior import expertise. We work with logistics companies to deliver your goods door-to-door with real-time tracking.

Packaging & Transportation

Standard packaging is aluminium foil bags of 1kg with nitrogen flushing for samples and trial orders. Bulk quantities are sent in 25kg fibre barrels with double food grade PE lining for moisture protection in transportation.

Custom packaging services include:

• Private label design and printing
• Customized container sizes (5kg, 10kg, 20kg)
• Vacuum-sealed packaging for extended shelf life
• Retail-ready bottles and containers

All packaging materials meet food-grade requirements. We mark items with batch numbers, production dates, expiration dates and storage directions. Where required, transportation is carried out under temperature-controlled conditions to keep the product stable throughout the supply chain.

After-Sales Service Commitment

Our technical support staff is available 24/7 to answer formulation enquiries, application help and troubleshooting. We can supply you with comprehensive product data sheets, safety data sheets (SDS) and regulatory documents for your market registration requirements.

In case there are any quality problems, we will reply within 24 hours to investigate and resolve. Our quality assurance team works with you to analyse batch data and perform remedial steps if required.

Qualified customers are provided with free samples (10-50g) to check compatibility before bulk purchases. Technical advice services include formulation optimisation for optimum bioavailability and stability.

Industry Exhibitions & Presence

Xi'an Jiayuan Bio-tech regularly participates in international trade shows including:

• Supply Side West (Las Vegas)
• Vitafoods Europe (Geneva)
• CPHI Worldwide (Multiple locations)
• Natural Products Expo West (Anaheim)

The events provide you the chance to meet our staff, see examples of the products and discuss special needs in person. Come and visit our stand to see the latest technological breakthroughs and application improvements.

 
Why Choose Xi'an Jiayuan Bio-tech?

Advantages for Direct Manufacturers

Why choose us Factory Direct price no middle man markups Competitive pricing Our integrated manufacturing plant means that we manage costs from raw material to final packaging, passing on savings to your procurement budget.

Capacity: Scalable Supply

We are located in China’s main milk thistle processing area (almost 70% of the world’s supply), which allows us to get high-quality raw materials all year round. Monthly ton-level capacity is suitable for both small trial order (MOQ 1kg) and high scale commercial contract. Lead times are consistent: 3-7 working days for standard goods, 7-15 days for customised requirements.

Technical Skills

We have 30 technical team including professional chemists and quality specialists with over 20 years experience in botanical extraction. We help you optimise formulation, boost bioavailability plans and document regulatory compliance for your target markets.

Customisable Flexibility

We can provide bespoke grades of silymarin ranging from 70%-98% potency, and various particle sizes, including water-soluble grades. We provide OEM/ODM service, including formula formulation, stability testing and private label production, to meet your brand needs.

Full Documentation

Full regulatory support is supplied with every shipment (COA, heavy metal, microbiological, allergy statements, GMO-free, BSE/TSE-free certifications, etc.) We develop documentation packages for FDA, EFSA and other regulatory filings.

FAQ 

Q: What purity grade and quality criteria are there?

A：We have several purity levels for different application requirements. Total silymarin content varies from 70% to 98% (USP norm ≥90%) and is constituted of silybin A/B (40-65%), silydianin/silychristin (20-45%) and isosilybin A/B (10-20%). Products comply with the norms of USP and Chinese pharmacopoeia. Main specifications include moisture ≤5.0%, heavy metals Pb ≤2 ppm, TPC ≤10⁴CFU/g, Salmonella/E. coli not detectable. Certifications include ISO, HACCP, KOSHER, HALAL. Each order has a COA; third-party reports available.

Q: How do you ensure batch-to-batch stability?

A：China is the world's largest milk thistle processing base, with Panjin City alone producing over 1,400 tons of silymarin annually (>70% of global production). We implement strict raw material sourcing from controlled farms and maintain consistent extraction processes. Each batch undergoes HPLC testing for silymarin profile verification to ensure content consistency. COA provided with each shipment, with retain samples kept for two years.

Q: What is the lead time?

A：MOQ stands at 1kg for standard orders. Lead time runs 3-7 working days for stock items and 7-15 days for customized specifications (specific purity, particle size, or private label packaging). Our monthly supply capacity reaches ton-level volumes.

Q: What packaging and shipping methods are available?

A：Packaging includes 1kg aluminum foil bags for samples and 25kg fiber drums with double food-grade liners for bulk orders. Custom packaging and OEM/private label options are available. Shipping methods include express delivery (3-5 days for small orders), air freight (5-7 days for medium quantities), and sea freight (20-35 days for bulk). Payment terms: T/T (30% deposit, 70% against B/L), L/C at sight, Western Union, and PayPal.

Q: Do you provide samples before bulk orders?

A：Yes, we offer free samples (10-50g) for qualified commercial buyers to conduct compatibility and quality testing. Sample shipping costs are typically borne by the customer, but we can discuss arrangements for serious purchase inquiries.

Contact Us

Ready to source premium Milk Thistle Extract Powder for your formulation needs? Contact our sales team at sales@jayuanbio.com and sales1@jayuanbio.com  for quotations, technical specifications, or sample requests. We respond to inquiries within 12 hours.