Betulinic Acid Powder

High-Purity Betulinic Acid Powder – Premium Natural Triterpenoid Extract for Pharmaceuticals, Nutraceuticals & Cosmeceutical Applications

Xi'an Jiayuan Bio-tech Co., Ltd., founded in 2002, with registered capital RMB 30 million, providing pharmaceutical quality Betulinic Acid Powder from Betula alba L. bark, standardised to 98% purity. Our white crystalline powder (CAS No. 472-15-1, Molecular Formula C30H48O3) is produced by a team of 30 technical professionals in two GMP-certified manufacturing lines. 20+ years of extraction experience. ISO9001/FSSC22000/HALAL/KOSHER certified. Factory direct prices and scalable production capacity. We solve the three biggest B2B pain points: stability of bioactives in tabletting, batch-to-batch consistency of APIs, and cost effective sourcing for global formulators.

What Is Betulinic Acid Powder?

The product is a naturally occurring pentacyclic lupane type triterpenoid from white birch bark. This bioactive molecule has multi-pathway therapeutic potential unlike synthetic derivatives via NF-κB inhibition, mitochondrial membrane permeabilization and apoptosis induction in aberrant cells.

High purity betulinic acid is a solution to formulation problems of low solubility in water (requiring sophisticated delivery devices) and oxidative instability during storage in the supply chain of pharmaceutical raw materials. We have a 98% standard for high bioactivity per gramme, meaning less excipients in capsules or topicals.

The lipophilic nature of the substance permits the transdermal penetration through cosmeceutical matrices. It targets the inflammatory cascades in the skin which water soluble actives can not penetrate.

 

Specifications

Product Name	Betulinic Acid Powder
Ref standard	Enterprise standard
Items	Requirements		Results
Appearance	White crystalline powder		Conforms
Content	≥ 98%		98.16%
Loss on drying	≤5.0%		1.69%
Heavy metal	≤10ppm		Conforms
Ash content	≤5.0％		0.10%
Lead	≤2ppm		Conforms
Arsenic	≤2ppm		Conforms
Mercury	≤1ppm		Conforms
Total Bacteria	≤1000cfu/g		Conforms
Yeast Mold	≤100cfu/g		Conforms
Conclusion	The product conforms to the enterprise standard

Functions

Biological Activity	Mechanism	Industry Application
Cellular Regulation	Mitochondrial pathway modulation	Oncology research compounds
Anti-inflammatory Action	Cyclooxygenase (COX-2) inhibition	Dermatological APIs
Antimicrobial Properties	Bacterial membrane disruption	Preservative systems
Metabolic Support	Insulin sensitivity modulation	Blood sugar management formulas
Antioxidant Defense	Free radical scavenging	Anti-aging cosmetic actives

The compound demonstrates superior stability compared to polyphenolic antioxidants. Its crystalline structure withstands high shear mixing in emulsion systems.

Application Fields

1. Pharmaceutical Development (B2B)

Betulinic acid is a lead chemical for drug discovery programmes on chronic inflammatory diseases. It is formulated as transdermal patches or liposomal solution to overcome bioavailability issues associated with triterpenoids. Advanced nano-encapsulation methods improve its therapeutic index in clinical studies.

2. Nutraceuticals formulations (B2B/B2C)

It is included in softgel capsules or powder blends used in metabolic wellness supplements and aids in the maintenance of healthy glucose metabolism and cellular antioxidant systems. This is compatible with omega-3 carriers and increases the intestinal absorption rates compared to the crystalline forms by themselves.

3. Functional Cosmeceuticals (B2B)

Betulinic Acid Powder controls the differentiation of sebocytes and the production of melanin. It is used in acne serums and treatments for post-inflammatory hyperpigmentation. Because it doesn't cause acne, it's a great ingredient for day creams that help skin types with oily skin.

 

Certificates

• ISO9001:2015 Quality Management System
• FSSC22000 Food Safety Certification
• HALAL & KOSHER Compliance
• HACCP System Certification
• SGS Third-Party Validation Reports

Quality Control

Our quality assurance protocol encompasses:

• Raw Material Authentication: HPLC fingerprinting against USP/EP reference standards
• Microbial Testing: Total plate count <1,000 CFU/g (符合 pharmacopoeia limits)
• Heavy Metal Screening: Pb <2ppm, As <1ppm per FDA guidelines
• Residual Solvent Analysis: GC-MS verification per ICH Q3C standards
• Stability Studies: 24-month shelf life under controlled storage (below 25°C, protected from light)

Each batch includes a Certificate of Analysis (CoA) documenting purity, moisture content (<5%), and particle size distribution.

Payment & Shipment

Payment Type: TT, DP, PayPal, Visa, LC, MasterCard, Escrow

Logistics Partners Fedex, DHL, EMS, UPS, TNT, International Air/Sea Freight

Lead Time : 7-10 business days upon payment confirmation

Customs Support: Door to door clearance for EU/US markets

We provide proactive shipment monitoring and paperwork (MSDS, CoA, phytosanitary certifications) to support your import operations.

Packaging & Delivery

Standard Packaging: 1kg/aluminum foil bag, 25kg/fiber drum with double PE lining

Special Options: Moisture-sensitive markets vacuum-sealed packaging

Storage Store in a cool, dry place away from direct light

Transport Classification: General non-hazardous cargo

All packing conforms with IATA/IMDG rules for overseas shipment.

Transportation​​​​​​​

After-sales Service

Our 24/7 technical support team assists with:

• Formulation troubleshooting (solubility enhancement, stability optimization)
• Regulatory documentation for novel food/cosmetic ingredient filings
• Analytical method transfer for in-house QC labs
• Sample replacement for R&D validation studies

We maintain close post-delivery communication to ensure your production success.

Exhibitions

Xi'an Jiayuan Bio-tech regularly participates in:

• SupplySide West (Las Vegas)
• Vitafoods Europe (Geneva)
• CPHI Worldwide
• Natural Products Expo

Visit our booth to discuss custom specifications and bulk order solutions.

Why Choose Us?

✅ Direct Manufacturer: Eliminate middleman markups with factory pricing

✅ Flexible MOQ: Consolidate multiple extracts in single shipments

✅ Technical Expertise: Two decades of triterpenoid extraction know-how

✅ Certified Quality: Multi-standard compliance (ISO/HALAL/KOSHER)

✅ Global Logistics: Seamless delivery to 60+ countries

✅ ODM/OEM Services: Custom potency blends and private labeling

 

FAQ

Q: What is the minimum order quantity for the product?

A: MOQ is 1kg normally, however we can do less for R&D reason. Order in bulk above 100kg and you will qualify for the discount tiers.

Q: How do you guarantee batches are consistent?

A: HPLC analysis of all manufacturing batches is done in triplicate. We save reference samples for 5 years to do comparison testing.

Q: Do you give regulatory expertise to assist innovative ingredient approvals?

A: Yeah. We provide full dossiers with toxicological data, stability studies and flow charts of manufacturing process according to EFSA/FDA regulations.

Q: What is the typical lead time for custom specifications?

A: Custom potency development requires 15–20 business days. We offer free pre-production samples (10–50g) for qualification trials.

Q: Do you offer solubility-enhanced versions?

A: Absolutely. We provide co-processed forms with cyclodextrins or phospholipid complexes to improve aqueous dispersibility in liquid formulations.

Contact Us

Ready to source premium Betulinic Acid Powder for your next formulation? Request your complimentary sample and technical data sheet today.

📧 Email: sales@jayuanbio.com and sales1@jayuanbio.com