Menadione Powder

Menadione Powder – Synthetic Vitamin K3 Compound for Feed & Nutrition Industries with High Bioavailability

Xi'an Jiayuan Bio-tech Co., Ltd. offers pharmaceutical-grade Menadione Powder (Vitamin K3, CAS: 58-27-5), manufactured through precision synthesis technology that ensures ≥99% purity and consistent particle distribution. We are direct manufacturer since 2002 with more than 20 years experience, with two GMP certified manufacturing lines and ISO9001 compliant quality processes. We ship over 50 tonnes a year to the worldwide market from our facility of 30 technical personnel. It is a white crystalline powder and an important coagulation factor precursor and bone metabolism regulator for animal feeding and medicinal uses.

What Is Menadione Powder?

The product is a synthetic derivative of Vitamin K3, a lipid-soluble naphthoquinone derivative which serves as a provitamin. Unlike vitamin K1 (phylloquinone) and K2 (menaquinone), menadione is not naturally occurring and must be converted inside the body to its active forms.

In commercial applications, it overcomes a key formulation problem: persistent vitamin K activity in heat-treated feeds and medicinal formulations where natural vitamins deteriorate quickly. Its crystal structure is more stable on the shelf (24+ months) than natural alternatives.

The compound exhibits excellent dispersibility in oil-based premixes and demonstrates reliable bioconversion rates in monogastric animals and poultry systems.

COA of Menadione Powder

Product Name	Menadione Powder
Lot No	240402	Quantity	2500kg
Manufacture Date	2024.04.10	Expiry Date	2026.04.09
Ref standard	Q/XK 172-2018
Items	Requirements	Results	Method
Appearance	White crystalline powder	White crystalline powder	visual
MSB content	≥96.0%	98.8%	uv
menadione	≥50.0%	51.5%	uv
sodium bisulfite;	≤5.0%	4.2%	Iodometry
Water content	≤13.0%	11.2%	Karl-fischer
Colour and lustre	≤Yellow-green standardized color solution No. 4	Conforms	Colorimetric method
Menaphthoquinone sulfonate test	Precipitation must not occur	No precipitation	Qualitative method
Chromium（Cr）	≤45.0mg/kg	41.0mg/kg	Original absorption method
Heavy metal	≤20 mg/kg	＜15mg/kg	Colorimetric method
Arsenic (As)	≤2mg/kg	＜1mg/kg	Arsenic spot method
Conclusion	The product conforms to the Q/XK 172-2018 standard

Functions

Primary Function	Mechanism of Action	Benefit
Blood Coagulation Support	Activates hepatic synthesis of prothrombin (Factor II) and Factors VII, IX, X	Reduces hemorrhagic incidents in livestock
Bone Matrix Mineralization	Facilitates γ-carboxylation of osteocalcin	Enhances skeletal development in young animals
Antioxidant Co-factor	Participates in electron transport chain regulation	Supports cellular health under oxidative stress
Growth Promotion	Optimizes nutrient utilization efficiency	Improves feed conversion ratio (FCR) by 8-12%

Application Fields

The product finds extensive use across three core industrial sectors:

Animal Feed Industry: Incorporated in poultry, swine and aquaculture premixes at 2-5 mg/kg feed. It inhibits nutritional-deficiency-induced bleeding problems and increases hatchability in breeding.

Pharmaceutical Manufacturing: Used as an active pharmaceutical ingredient (API) in injectable solutions for hypoprothrombinemia. It is a raw ingredient for the creation of the tablet and capsule to treat the vitamin K deficiency.

Veterinary Medicine: Incorporated into therapeutic formulations for the treatment of anticoagulant rodenticide toxicity in companion animals. It gives a fast supply of vitamin K in clinical emergencies.

Quality Control

We have six key control points in our quality assurance methodology. Raw material verification starts with spectroscopic analysis and heavy metal screening to guarantee contamination-free inputs.

Particle size distribution (D50: 20-40 μm) is monitored in process and crystallinity is determined by X-ray diffraction. Each manufacturing batch is validated by HPLC test with a purity of ≥99%.

Microbiological Testing - USP <61> & <62> Microbial Limits: Total plate count <1000 CFU/g Pathogen Tolerance: None Stability studies according to ICH criteria provide a shelf life of 24 months at room temperature.

GC-MS analysis of residual solvents to meet pharmaceutical grade standards. With every shipment you will get comprehensive analytical paperwork, Certificate of Analysis, batch records and stability data.

Certificates

• ISO9001:2015 Quality Management System
• SGS Third-Party Inspection Reports
• HALAL Certification for Global Markets
• High-tech Enterprise Certificate (Shaanxi Province)

Payment & Shipment

We accept flexible payment terms including T/T, L/C, and PayPal for Menadione Powder for established customers. A free 10-20g sample is available to verify quality before bulk ordering.

Our logistics network is partnered with FedEx, DHL, UPS and TNT for air express delivery (5-7 days). We can ship big orders above 500kg via sea shipping. If you don’t have expertise with import, we will perform the customs clearance for you door-to-door in Europe and the USA so that it arrives at your facility without any problems.

Packaging & Transportation

Standard packing is 25kg fibre drums with double food grade polyethylene bags inside. Other packing methods include 1kg foil bags or special tiny packages according to your needs.

All containers are sealed with tamper evident seals and are labelled with batch numbers, manufacture dates and storage instructions. The product is stable when kept below 25°C in dry circumstances and protected from direct sunlight.

We palletise using moisture-proof and shock-absorbing materials for container loading. Temperature controlled shipping available on request to ensure product integrity throughout transit.

After-sales services

Our technical support staff can advise on the best formulation inclusion rates for your particular application. We do stability compatibility testing with additional substances.

If quality concerns develop, we will reply within 24 hours with investigative processes and remedial activities. Any material not meeting approved requirements will be replaced or refunded.

We are still here to help our customers, including updates on regulatory documents and industry trends. We keep the lines of communication open to accommodate your changing technological needs.

Exhibitions

Xi'an Jiayuan Bio-tech regularly participates in international trade shows including:

• Vitafoods Europe (Geneva)
• SupplySide West (Las Vegas)
• CPHI Worldwide (Pharma Ingredients)
• VIV Asia (Animal Nutrition)

These shows are also great chances for face-to-face consultations and live product demonstrations. Come visit our booth and talk about unique specs and collaboration prospects.

Why Choose Us?

manufacturer-Direct Sourcing: Skip the middleman markups and purchase directly from the manufacturer. Our vertical integration saves you 15-25% procurement expenses compared to trading organisations.

Flexible MOQ Policy: Buy ingredients in the Smaller Quantities, Multiple Items. This way you lower your inventory carrying expenses and enable fast formulation changes.

Technical skills: We have a 30-person R&D staff for application support and debugging. You have access to analytical testing resources and formulation optimisation services.

WORLDWIDE LOGISTICS EXCELLENCE: 20+ Years Export Experience We know our way around complicated International Regulations. Customs clearance help streamlines your import procedure.

FAQ

Q: What's the difference between Menadione and natural Vitamin K?

A: Menadione (Vitamin K3) is a synthetic precursor to be metabolically converted whereas K1 and K2 are active naturally occurring forms. Menadione is more heat stable and cost economical to use in industry.

Q: What is the suggested storage condition ?

A: Store in sealed containers in dry, well-ventilated places at temperatures below 25°C. Shelf life 24 months when stored in a cool, dry place, away from direct sunlight.

Q: Can you provide technical support for formulation development?

A: Yes, our technical team assists with dosage recommendations, stability testing, and compatibility evaluations. We provide detailed incorporation guidelines for various delivery systems.

Q: What are the minimum order quantities?

A: Standard MOQ is 25kg (one drum). Smaller quantities may be negotiated for initial trials or multi-product orders.

Q: Do you offer customized packaging options?

A: Absolutely. We accommodate custom packaging requests including private labeling, specialized container sizes, and modified atmosphere packaging for sensitive applications.

Contact Us

Ready to secure consistent, high-quality Menadione Powder for your operations? Contact our sales team at sales@jayuanbio.com and sales1@jayuanbio.com today to request samples, technical specifications, or quotations. Let's build your reliable supply solution together.