Piperine Powder

High-Purity Piperine Powder 95%-98% | Bioavailability Enhancement Solution for Nutraceutical Manufacturing

Xi'an Jiayuan Bio-tech Co., Ltd., established in 2002 with RMB 30 million registered capital, delivers pharmaceutical-grade Piperine Powder extracted from Piper nigrum L. seed. Our standardized extract is a light yellow to white crystalline powder and is available in 95% and 98% purity grades (HPLC certified). We have two GMP-approved manufacturing lines and we are ISO9001, HALAL and KOSHER certified, with content variability from batch to batch controlled at ±2%. We employ 30 technical professionals at our plant who provide consistent quality for our worldwide nutraceutical and pharmaceutical customers requiring dependable bioavailability-enhancing raw ingredients.

What Is Piperine Powder?

The product is the main alkaloid ingredient extracted from black pepper fruits by solvent extraction and crystallization purification. This lipophilic molecule has chemical formula C17H19NO3 and molecular weight 285.34. It has a melting point of 128°C-132°C. This material is practically insoluble in water and easily soluble in ethanol, chloroform and ether.

Our standardized extract offers precise formulation consistency unlike conventional pepper powder which has varying essential oils and starches. The material is screened through 80 mesh (100% pass) to provide a homogeneous mix in solid dosage applications.

COA of Piperine Powder

Product Name	Piperine Powder
Ref standard	Enterprise standard
Items	Requirements	Results	Method
Appearance	Pale yellow to white powde	Conforms	Visual
Odor	Unique smell	Characteristic	Organoleptic
Assay	＞95%	95.77%	HPLC
Bulk Density	Slack Density 69.76g/100ml	43.6g/100ml	USP616
	Tight Density	69.76g/100ml	USP616
Particle size	95% pass 80 mesh	Conforms	CP2015
Piperine	≥98.0%	98.01%	HPLC
Water content	≤1.0%	0.23%	CP2015 (105 oC, 4 h)
Ash	≤1.0%	0.15%	CP2015
Heavy metal	＜10.0ppm	Conforms	CP2015
Total Plate Count	≤1000cfu/g	Conforms	GB4789.2
Mold &Yeast	≤100 cfu/g	Conforms	GB4789.15
E. Coli	＜3MPN/g	Conforms	GB4789.38
Salmonella species	Non-detected	Conforms	GB4789.4
Staphylococcus aureus	Non-detected	Conforms	GB4789.10
Conclusion	The product conforms to the enterprise standard

Functions

This chemical is a wide-range bioavailability enhancer acting via selective regulation of CYP3A4 enzymes and P-glycoprotein transporters. Clinical studies have shown significant increases in absorption, bioavailability of curcumin by some 2000%, coenzyme Q10 by 30%, vitamin B6 by 50%, and β-carotene by 60%.

Moreover, the active ingredient has several pharmacological properties besides the improvement of nutritional absorption. It provides antioxidant protection via methods of free radical scavenging. Regulation of NF-κB pathway and anti-inflammatory effects. The chemical stimulates production of enzymes, therefore enhancing digestive function.

Features of metabolic regulation assist processes of fat metabolism Neuroregulatory actions include regulation of the serotonin and dopamine pathways. Immune-boosting properties bolster the body's natural defensive mechanisms.

Application Fields

Dietary Supplements

Add 0.5-2.5mg per serving to formulations containing curcumin, berberine, coenzyme Q10, or multivitamin complexes. The low dosage requirement delivers significant efficacy upgrades without affecting product stability.

Sports Nutrition Products

Incorporate 1-5mg per serving to enhance absorption of performance-supporting nutrients. The compound complements fat metabolism formulations effectively.

Functional Foods

Suitable for fortified food applications requiring enhanced nutrient delivery systems. The material blends uniformly in powder matrices.

Pharmaceutical Applications

Applicable in drug formulations requiring improved bioavailability profiles, subject to regulatory compliance and professional oversight.

Certificates

We have full international certifications for our production plant. ISO9001 Quality Management System, FSSC22000, HACCP, KOSHER and HALAL certifications. Our technological strength is shown by the recognition as Private Science and Technology Enterprise of Shaanxi Province and High-tech Enterprise. Every shipment of Piperine Powder includes a Certificate of Analysis with complete test documentation.

Quality Control

Our quality assurance system maintains rigorous specifications across production batches:

Parameter	Specification
Assay (HPLC)	95% / 98%
Appearance	Pale yellow to white powder
Loss on Drying	≤5.0%
Heavy Metals	≤10ppm
Lead (Pb)	≤3ppm
Arsenic (As)	≤2ppm
Cadmium (Cd)	≤1ppm
Particle Size	100% pass 80 mesh
Shelf Life	24 months

Each production run undergoes third-party laboratory verification. HPLC assay data and stability reports accompany every batch. Residual solvents comply with USP and EP standards, with ethanol/methanol content maintained below 5000ppm per USP <467> guidelines.

Payment & Shipment

Payment Terms: We accept T/T (Telegraphic Transfer), L/C (Letter of Credit), PayPal, Western Union, MoneyGram, and Alibaba Trade Assurance. T/T remains the most common settlement method for commercial orders.

Delivery Options:

Courier service (<100kg): 3–5 days door-to-door via FedEx, DHL, EMS, UPS, TNT

Air freight (100–1000kg): 5–7 days airport-to-airport

Sea freight (>300kg): Production time plus approximately 30 days port-to-port

For clients lacking import experience, we provide customs clearance assistance in Europe and North America, ensuring products reach your facility directly.

Packaging & Transportation

Standard packaging is in 25kg fiber drums with twin PE bag liners to avoid contamination. Smaller amounts are sent in foil bags of 1kg with nitrogen flushing. All containers are light-proof and moisture-resistant to avoid photo-oxidation.

Store in cold, dry, dark conditions below 25°C. Keep containers closed to protect product integrity during the 24 month shelf life. As partners we work with large international logistics companies to provide temperature-controlled transit where needed.

After-sales Service

Our technical support staff is available 24/7 to help with formulation advice, regulatory documents and application difficulties. Commercial customers that qualify may get complimentary samples (usually 10-50g) to do testing before making a purchase. We do not supply retail quantities to individual consumers.

Customization services support both ODM and OEM requirements. Adjust purity specifications, particle size distribution, or packaging formats according to your production needs. Our flexible warehouse stocking service helps optimize your inventory management.

Exhibitions

We regularly participate in international industry exhibitions including Supply Side West, Vitafoods Europe, and CPHI Worldwide. These platforms allow direct technical exchanges with global partners and demonstrate our latest quality improvements. Visit our booth to discuss custom solutions for your specific applications.

Why Choose Us?

20+ Years Manufacturing Experience: Since 2002, we have refined extraction and purification processes to deliver consistent pharmaceutical-grade materials.

Direct Factory Pricing: Eliminate intermediary markups. Our integrated production model provides cost-effective supply solutions with flexible minimum order quantities for multiple product purchases.

Scalable Production Capacity: Monthly output supports ton-level orders with stable supply continuity. Our two GMP production lines ensure uninterrupted fulfillment even during peak demand periods.

Strict Quality Control : Our technical team of 30 people controls every manufacturing step from the procurement of raw materials to the final inspection. Professional laboratory facilities provide a full range of testing: HPLC, heavy metals, residual solvents, microbiological.

Global Logistics Network: We partner with major airlines to provide efficient delivery globally. International customers find customs clearance support easier to navigate.

Technical Innovation: Competitive edge via advanced extraction technology and equipment upgrades. Our R&D skills allow tailored specifications to satisfy increasing market needs.

FAQ

Q：How is quality consistency ensured across batches?

A：Each batch includes third-party verifiable COA documentation. Batch-to-batch purity deviation stays within ±1.0%. We provide HPLC assay data and stability reports supporting the 2-year shelf life claim.

Q：What is the lead time?

A：Sample orders ship within 3–5 working days. Commercial orders require 7–10 days. Bulk sea freight adds approximately 30 days shipping time to production schedules.

Q：Why does powder color vary between batches?

A：Color ranges from pale yellow to white depending on purity level. Higher purity grades (>98%) appear whiter, while 95% may retain natural resins from pepper fruits.

Q：Is the material stable under high-heat manufacturing?

A：Stability maintains up to the melting point (~128°C), but prolonged aqueous exposure at elevated temperatures may cause degradation. Dry blending methods are preferred for formulation.

Q：What storage conditions prevent degradation?

A：Use light-proof, airtight containers stored below 25°C. This prevents photo-oxidation and isomerization that compromise product efficacy.

Q：How does it interact with medications?

A：The compound inhibits CYP3A4 metabolic enzymes, potentially increasing blood concentrations of certain pharmaceuticals like phenytoin and propranolol. Professional formulation oversight is required for combination products.

Contact Us

Ready to enhance your formulation's bioavailability with Piperine Powder? Reach our sales team at sales@jayuanbio.com and sales1@jayuanbio.com for quotations, COA certificates, or custom specification discussions.