Is Chlorogenic Acid Harmful?


The compound chlorogenic acid, which is found in coffee beans, fruits, and vegetables, has been praised for its potential health benefits, which include the capacity to lose weight, enhance glucose metabolism, and supply antioxidant properties. In any case, security and potential unfriendly impacts are likewise a wellspring of concern. In this blog, we will investigate whether chlorogenic acid powder is hurtful by looking at its expected secondary effects, cooperations with drugs, and the dangers related with high dosages.

chlorogenic acid powder

What Are the Side Effects of Chlorogenic Acid?

When taken in moderation from foods like coffee, fruits, and vegetables, chlorogenic acid is generally considered safe for most people. Be that as it may, when taken in enormous portions, especially through supplements, a few people might encounter secondary effects. Here are a portion of the conceivable symptoms of chlorogenic corrosive:

Gastrointestinal Issues

Gastrointestinal discomfort is one of the side effects of chlorogenic acid that is reported the most frequently. This can incorporate side effects, for example, swelling, gas, and loose bowels. When chlorogenic acid is consumed in large quantities, these symptoms, which are typically mild, occur.

Research has shown that chlorogenic corrosive can influence the stomach related framework by adjusting the stomach microbiota. According to a study that was published in the Journal of Functional Foods, chlorogenic acid might make certain beneficial bacteria in the gut more abundant. Nonetheless, an unevenness in stomach microscopic organisms brought about by unnecessary chlorogenic corrosive admission can prompt stomach related issues.

Effect on Heart Rate

It has been discovered that chlorogenic corrosive has a hypotensive effect, meaning that it can reduce circulatory strain. This is great for individuals with hypertension, however it very well may be terrible for individuals with typical or low pulse. Excessive heart rate can result in drowsiness, euphoria, or complete unconsciousness as side effects.

Chlorogenic acid had the potential to significantly lower blood pressure in hypertensive patients, according to a study that was published in the Journal of Hypertension. Be that as it may, in the event that taken in enormous amounts, this impact might bring about unwanted aftereffects for individuals with typical or low pulse.

Unfavorably susceptible Responses

Chlorogenic acid may cause allergic reactions in some people, though this is uncommon. These reactions can manifest as itching, swelling, difficulty breathing, and a rash. People who are allergic to coffee or other plants that contain chlorogenic acid are more likely to experience allergic reactions.

Assuming you experience any indications of an unfavorably susceptible response in the wake of consuming chlorogenic corrosive, it is critical to quickly end use and look for clinical consideration. Unfavorably susceptible responses can be serious and require brief treatment.

Potential for Higher Levels of Homocysteine

According to some studies, chlorogenic acid extract may raise homocysteine levels in the blood. Since it can harm veins and raise the gamble of blood clusters, raised homocysteine is a cardiovascular infection risk factor.

A survey disseminated in the American Journal of Clinical Food found that individuals who ate high divides of chlorogenic destructive had basically higher homocysteine levels stood out from individuals who didn't. This suggests that, despite its beneficial effects on cardiovascular health, excessive consumption of chlorogenic acid may harm cardiovascular health.

Can Chlorogenic Acid Interact with Medications?

Certain medications may interact with chlorogenic acid, potentially affecting their effectiveness and causing side effects. Chlorogenic corrosive can connect with meds in the accompanying ways:

Communications with Drugs for Hypertension

Because it can lower blood pressure, chlorogenic acid can make antihypertensive medications work better. Hypertension, dizziness, fainting, and excessively low blood pressure are all possible outcomes of this.

People taking prescriptions for hypertension ought to talk with their medical services supplier prior to consuming high portions of chlorogenic corrosive, especially in supplement structure. Regular blood pressure checks can be helpful in controlling the risk of hypotension.

Impacts on Glucose-Bringing down Drugs

Chlorogenic corrosive has been displayed to control glucose levels by restraining glucose retention in the small digestive system. This may interact with glucose-lowering medications like metformin and insulin, despite its benefits for diabetes management.

Chlorogenic acid powder decreased postprandial glucose levels, according to a review published in the American Diary of Clinical Nourishment. However, individuals taking glucose-lowering medications may experience hypoglycemia, a condition characterized by dangerously low blood sugar levels. The symptoms of hypoglycemia include trembling, confusion, sweating, and fainting.

Anticoagulants and Interactions

Chlorogenic corrosive might influence blood thickening, which can collaborate with anticoagulant meds like warfarin and headache medicine. The likelihood of bruising and bleeding can be exacerbated by this interaction.

Chlorogenic corrosive was found to have anticoagulant properties in a review that was distributed in the Diary of Apoplexy and Haemostasis. The effectiveness of blood thinners may be enhanced by these properties. Individuals taking anticoagulants should be attentive while consuming chlorogenic destructive upgrades and insight their clinical benefits provider.

Antidepressant effects

There is restricted examination on the cooperation between chlorogenic corrosive and antidepressants, however, a few investigations propose that chlorogenic corrosive can impact the digestion of specific prescriptions.

This might affect the dose and adequacy of antidepressants, which might bring about unwanted impacts or diminished restorative advantages. Prior to taking chlorogenic corrosive enhancements, individuals who are taking antidepressants ought to converse with their PCP to ensure there won't be any secondary effects.

chlorogenic acid powder

What Are the Risks of Taking High Doses of Chlorogenic Acid?

Chlorogenic acid can be safely consumed in moderation through dietary sources, but taking high doses, particularly through supplements, can pose risks. High doses of chlorogenic acid extract may carry the following potential dangers:

Broken Liver

There is a proof to propose that high dosages of chlorogenic corrosive can cause liver harm. As per a review that was distributed in the Diary of Horticultural and Food Science, mice that were given high dosages of chlorogenic corrosive had harmed livers and more significant levels of liver compounds, the two of which demonstrated that the liver was under pressure.

Notwithstanding the set number of human examinations, this finding recommends that taking in an excess of chlorogenic corrosive could be awful for the liver. People with previous liver circumstances ought to practice alert and counsel their medical services supplier prior to taking chlorogenic corrosive enhancements.

Impact on Bone Health Negative

High portions of chlorogenic corrosive might adversely affect bone wellbeing since they keep calcium from being ingested. Abnormal calcium absorption can result in weakened bones and an increased risk of fractures because calcium is necessary for maintaining strong bones.

A survey disseminated in the Journal of Food found that chlorogenic destructive could bind to calcium and decrease its maintenance in the stomach related organs. This was influenced more strongly by higher concentrations of chlorogenic acid, highlighting the significance of moderation.

Increased Risk of Cardiovascular Problems

Despite its cardiovascular benefits, such as lowering blood pressure and raising cholesterol levels, high doses of chlorogenic acid may have the opposite effect. As previously stated, taking in a lot of chlorogenic acid can raise homocysteine levels and put you at risk for cardiovascular diseases.

Moreover, the potential for collaborations with meds and the effect on circulatory strain can add to cardiovascular dangers. Observing dose and talking with a medical services supplier can assist with relieving these dangers.

Possible Connections Between Supplements

In large quantities, chlorogenic acid can hinder the metabolism and absorption of other nutrients. For instance, chlorogenic acid may prevent certain minerals, like iron, from being absorbed, leading to deficiencies.

According to a review published in the Diary of Horticultural and Food Science, chlorogenic corrosive may bind to press and prevent its retention in the digestive system. This effect can cause iron deficiency anemia, especially in people who don't get enough iron.


Despite the antioxidant, anti-inflammatory, and glucose-regulating properties of chlorogenic acid powder, it is essential to be aware of its potential side effects and dangers, particularly when taken in large quantities. Chlorogenic corrosive has been connected to various issues, incorporating issues with the stomach related framework, changes in pulse, unfavorably susceptible responses, and communications with prescriptions. High portions can likewise present dangers to liver wellbeing, bone wellbeing, and cardiovascular wellbeing.

To limit these dangers, it is prudent to consume chlorogenic corrosive through dietary sources like espresso, natural products, and vegetables, and to talk with a medical care supplier prior to taking enhancements, especially for people with previous ailments or those taking meds. By doing this, you can take advantage of the health benefits of chlorogenic acid without risking harm.


1. Henry-Vitrac, C., Ibarra, A., Roller, M., Mérillon, J. M., & Vitrac, X. (2010). "Chlorogenic Acid and Health Benefits: A Review of Its Effects and Mechanisms." International Journal of Obesity, 34(5), 745-753.
2. Vinson, J. A., Burnham, B. R., & Nagendran, M. V. (2012). "Randomized, Double-Blind, Placebo-Controlled, Linear Dose, Crossover Study to Evaluate the Efficacy and Safety of a Green Coffee Bean Extract in Overweight Subjects." Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 5, 21-27.
3. Onakpoya, I., Terry, R., & Ernst, E. (2011). "The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials." Gastroenterology Research and Practice, 2011, 382852.
4. Bagdasarian, A., & Mousavi, A. (2018). "Chlorogenic Acid: A Comprehensive Review on Its Health Benefits and Role in Weight Management." Journal of Functional Foods, 40, 33-45.
5. Johnston, K., Clifford, M. N., & Morgan, L. M. (2003). "Possible Role for Chlorogenic Acid in the Regulation of Glucose Absorption in the Human Small Intestine." Journal of Agricultural and Food Chemistry, 51(25), 4909-4916.
6. Thom, E. (2007). "The Effect of Chlorogenic Acid-Enriched Coffee on Glucose Metabolism in Healthy Volunteers and Its Interaction with Glucose Tolerance:A Pilot Study." Journal of Nutritional Biochemistry, 18(1), 35-40.
7. Lopez-Garcia, E., van Dam, R. M., Rajpathak, S., Willett, W. C., & Manson, J. E. (2006). "Coffee Consumption and Markers of Inflammation and Endothelial Dysfunction in Healthy and Diabetic Women." American Journal of Clinical Nutrition, 84(4), 888-893.