N-Methyl-L-Serine

N-Methyl-L-Serine: Premium Pharmaceutical Grade Chiral Amino Acid from Certified Manufacturer

Xi'an Jiayuan Bio-tech Co., Ltd. produces pharmaceutical-grade N-Methyl-L-Serine with purity ≥98%, specifically designed for peptide synthesis and drug development applications. We produce our product in facilities that are ISO9001 certified. We fulfil international quality standards with tight control of optical rotation ([α]20/D +6.0° to +9.0°) to assure the purity of the L-enantiomer. We are direct manufacturer with more than 20 years experience. We have a competent team of 30 technical staff. 1. Competitive factory price. 2. Flexible MOQ beginning from 1kg. 3. Comprehensive worldwide logistics assistance. (FedEx, DHL, major carriers) We have two GMP certified manufacturing lines to provide a regular supply with consistent batch to batch dependability.

What Is N-Methyl-L-Serine?

Product (CAS: 2480-26-4) It is a derivative of non-proteinogenic amino acid, with methyl group connected to nitrogen atom of L-serine. This structural change makes it an indispensable chiral building material in contemporary pharmaceutical synthesis.

The molecule is a white crystalline powder, and is a strategic solution for improving peptide medication stability. Incorporation of this methylated amino acid into peptide chains greatly increases resistance to enzyme degradation and allows for fine-tuning of bioavailability.

Its unusual chemical framework (C4H9NO3, molecular weight 119.12) offers steric hindrance to protect therapeutic peptides from premature degradation in biological environments, making it essential to next-generation drug development.

COA

Product Name	N-Methyl-L-Serine
Lot No	240502		Quantity	400kg
Manufacture Date	2024.05.19		Expiry Date	2026.05.18
Ref standard	According with the enterprise standard
Items	Requirements			Results	Method
Assay	≥98%			98.61%	HPLC
Appearance	White crystalline powder			Conforms	Organoleptic
Taste	Characteristic			Conforms	Organoleptic
Ethanol	≤5000ppm			1118ppm	GC
Total Plate Count	≤5000cfu/g			Conforms	CP2015
Mold &Yeast	≤100 cfu/g			Conforms	CP2015
E. Coli	Negative			Not Detected	CP2015
Salmonella species	Non-detected			Not Detected	CP2015
Staphylococcus aureus	Non-detected			Not Detected	CP2015
Non-GMO, Non-Irradiation, Allergen Free
Storage Condition:	Preserve in tight containers at controlled room temperature .
Packing	25kg in drum with double plastic bag inside
Conclusion	The product conforms to the enterprise standard

Core Functions

The N-methyl modification has many functional benefits for your pharmaceutical research. It prevents hydrogen bonding sites throughout the peptide backbone, lowering vulnerability to protease enzymes that normally breakdown therapeutic peptides.

This chemical reduces the overall polarity of peptide structures and hence increases the permeability of the membrane. The methyl group imposes conformational limitations that force peptides into their bioactive forms, improving target binding affinity.

Additionally, it extends plasma half-life of peptide drugs, allowing for reduced dosing frequencies. This translates to better patient compliance and improved therapeutic outcomes in clinical applications.

Application Fields

Therapeutic Peptide Engineering

You can integrate N-Methyl-L-Serine into peptide-based drugs for metabolic disorders and oncology treatments. The compound protects peptidase attack sites, dramatically extending drug circulation time and reducing administration frequency.

Neurodegenerative Disease Research

Research teams utilize this compound in glutamate receptor signaling studies. Its structural similarity to neurotoxin BMAA makes it valuable for developing neuroprotective agents targeting ALS and Alzheimer's disease through competitive binding mechanisms.

Peptidomimetic Synthesis

In synthesizing cyclic peptides and depsipeptides, this amino acid acts as a conformational constrainer. It forces peptide backbones into specific beta-turns essential for high-affinity binding to G-protein-coupled receptors and other biological targets.

Quality Control

Every batch is tested rigorously to guarantee it complies with pharmaceutical-grade requirements via our quality assurance system.

HPLC Purity Analysis: We only accept batches with 98.0% purity or above, with unreacted L-Serine and dimethylated byproducts detected to provide you pure chemical for your stereoselective synthesis requirements.

Polarimetry: Optical Rotation Test validates L-configuration validity. If there is any variation showing the racemization, the batch is rejected immediately and your synthesis findings are protected.

Structural Verification: Required 1H-NMR and Mass Spectrometry to confirm placement of methyl groups and to rule out worries of residual solvent.

Moisture Control: Loss on Drying testing confirms that water content is less than 1.0% to avoid weighing mistakes important to the stoichiometric accuracy of your synthesis operations.

Contamination Screening: Heavy metals and ash content are tightly maintained below 10-20 ppm as per the norms of the international pharmacopoeia for downstream pharmaceutical uses.

Certificates

Xi'an Jiayuan Bio-tech is certified to ISO9001 Quality Management System and manufacture under GMP-standard manufacturing processes. Our company has been identified as a Private Science and Technology company and High-tech Enterprise of Shaanxi Province.

We also have other certifications like SGS verification and HALAL related certifications to meet the regulatory needs of different markets across the world.

Payment & Shipment

To facilitate your purchase we offer a variety of payment options, including T/T, Western Union, L/C. We send reliably globally via our connections with FedEx, DHL, EMS, UPS, TNT and other major international carriers.

We can facilitate customs clearance in Europe and the US and delivery of the goods straight to your facilities for new import clients, with less logistical complexity.

Packaging & Transportation

Standard Packaging 25kg drums, 1kg bags Custom Packaging Custom Packaging is available to suit your exact needs. All items are sealed in inert environment in moisture-proof containers for transport stability.

We use temperature regulated shipping techniques and store at 2-8°C or -20°C upon delivery. Our packaging conforms to the international safety regulations for the transport of chemical chemicals.

After-sales Service

Our technical support staff can advise on storage conditions, handling processes and application protocols. All shipments are provided with paperwork support like COA, MSDS and regulatory compliance certifications.

If you have any quality issues, our attentive customer care team will investigate and resolve the matter promptly, supported by our full quality guarantee policy.

Exhibitions

Xi’an Jiayuan Bio-tech consistently participates in major pharmaceutical and biotechnology exhibits worldwide to display our latest product breakthroughs and to engage with industry partners. These events give opportunity for face-to-face technical conversation and connection development.

Why Choose You?

Direct Manufacturer Advantages

We are a factory-direct provider since 2002 – cutting out the middlemen and providing low prices, yet maintaining top quality standards via our two GMP manufacturing lines.

Technical know-how

Our 30 expert technicians are experienced and can give application assistance and custom synthesis services to help you integrate N-Methyl-L-Serine into your research methods with ease.

Solutions, Flexible Order

We accept orders beginning from 1kg MOQ and have stock in the warehouse for rapid delivery. You may combine numerous product purchases to save on shipping costs and increase supply chain efficiency.

Global Reach. Local Support

If you’re new to foreign sourcing, our well-established customs clearance support in major markets throughout the globe can guarantee your import operations are seamless. We remove the complexity of logistics so you can concentrate on the study.

Consistent Supply Reliability

With RMB 30 million registered capital and robust production capacity, we guarantee stable supply and batch consistency critical for your ongoing pharmaceutical development projects.

FAQ

Q: Is the product prone to racemization during peptide coupling?

A: The N-methylation provides steric hindrance, which makes the molecule chiral-stable. However, for >99% chiral purity throughout your synthesis we advocate the use of HATU/HOAt coupling reagents and minimising exposure to base.

Q: What do I do with large amounts?

A: Store in firmly closed containers under nitrogen environment at -20oC or 2-8oC. Hygroscopic nature – to be protected from moisture to avoid clumping and deterioration.

Q: Can this substitute for L-Serine directly in any protocol?

A: No. The N-methyl group alters hydrogen bonding capacity and peptide folding patterns. It functions as a strategic substitution for specific stability and bioavailability improvements, not as a generic replacement.

Q: What is the solubility profile for stock solutions?

A: It dissolves readily in water and 1M HCl. For organic synthesis, Fmoc or Boc-protected derivatives improve solubility in DCM or DMF for standard peptide synthesis workflows.

Q: Is this product BSE/TSE free?

A: Yes. Our product is produced via chemical methylation of fermentation-derived L-Serine, ensuring it is BSE/TSE free and suitable for applications requiring synthetic origin documentation.

Contact Us

Ready to enhance your peptide synthesis projects with premium-grade N-Methyl-L-Serine? Contact our technical sales team at sales@jayuanbio.com and sales1@jayuanbio.com  for quotations, samples, or technical consultation.