High-Purity Madecassic Acid Powder for Advanced Skin Repair & Professional Formulation Solutions
Xi'an Jiayuan Bio-tech Co., Ltd. delivers pharmaceutical-grade Madecassic Acid Powder extracted from Centella asiatica (Herba), with standardized potency ranging from 10% to 95% HPLC. Our factory was founded in April 2002 with a registered capital of RMB 30 million. We have 2 GMP standard manufacturing lines, and 30 competent technical workers. This substance seems to be light yellow to white crystalline, chemical formula C30H48O6, CAS No. 18449-41-7. Our ISO9001 accredited quality standards provide batch to batch consistency and exceptional bioactivity for demanding pharmaceutical and cosmeceutical applications.
What Is Madecassic Acid Powder?
Centella asiatica produces a pentacyclic triterpene acid. It is one of four main active chemicals that provide the plant its wound-healing and anti-inflammatory properties.
High-purity product overcomes key formulation issues in B2B raw material supply chain. Standardised product guarantees the same bioactivity, which is a need for regulatory compliance in medicines and clinical-grade cosmetics, unlike generic Centella extracts with variable composition.
It weighs 504.70 and has particular placement of hydroxyl groups so that it may selectively interact with collagen production pathways and inflammatory mediators. This makes it essential for formulations where dependable therapeutic results are needed.
COA
| Product Name | Madecassic Acid Powder | ||
| Ref standard | According with the enterprise standard | ||
| Items | Requirements | Results | |
| Appearance | Light yellow to white powde | Conforms | |
| Odor | Characteristic | Conforms | |
| Taste | Characteristic | Conforms | |
| Assays | ≥98% | 98.79% | |
| Loss on drying | ≤5.0% | 2.03% | |
| Ash | ≤5.0% | 2.28% | |
| Sulphated ash | <1.0% | 0.607% | |
| Heavy metals | ≤10ppm | Conforms | |
| Arsenic | ≤1ppm | Conforms | |
| Lead | ≤2ppm | Conforms | |
| Hg | Absent | Conforms | |
| Assays(HPLC) | Total Triterpenes 10% | 10.12% | |
| Total Plate | ≤1000CFU/g | Conforms | |
| Yeast & Mould | ≤100CFU/g | Conforms | |
| E. Coli | Negative | Conforms | |
| Staphylococcus | Negative | Conforms | |
| Salmonella | Negative | Conforms | |
| Conclusion | The product conforms to the enterprise standard | ||
Functions
|
Function |
Mechanism of Action |
Application Advantage |
|
Collagen Synthesis Promotion |
Stimulates fibroblast proliferation and enhances Type I & III collagen production |
Accelerates wound closure in post-surgical and burn treatments |
|
Anti-Inflammatory Action |
Inhibits NF-κB pathway and reduces pro-inflammatory cytokine release (TNF-α, IL-6) |
Mitigates chronic inflammation in atopic dermatitis and rosacea formulations |
|
Antioxidant Protection |
Neutralizes free radicals and upregulates endogenous antioxidant enzymes (SOD, CAT) |
Prevents photoaging and oxidative stress damage in anti-aging cosmetics |
|
Scar Tissue Remodeling |
Regulates TGF-β signaling to balance extracellular matrix deposition |
Reduces hypertrophic scars and keloid formation in dermatological therapies |
Application Fields
1. Clinical Dermatology & Wound Care (B2B)
Your pharmaceutical-grade solution integrates well into prescription wound-healing gels and burn ointments. It is a non-steroidal replacement of corticosteroids and addresses the worry of physicians in long term usage of steroids in sensitive groups like paediatric or geriatric patients.
2. High Performance Cosmeceuticals (B2B)
Formulators apply our powder to luxury skincare post-procedure serums and barrier-repair creams. Restoring epidermal integrity solves the industrial problem of skin sensitivity following chemical peels, laser treatments, or retinoid use.
3. Oral & Topical Nutraceuticals (B2C)
For dietary supplement manufacturers, standardized product in capsule or tablet form supports systemic anti-inflammatory benefits. Topical patches containing this active also target localized joint discomfort through transdermal delivery.
Certificates
Our facility holds:
- ISO9001 Quality Management System Certification (2012)
- HALAL Certification for global market access
- SGS Supplier Verification
- Recognition as a High-tech Enterprise of Shaanxi Province (2013)
Documentation packages for regulatory submissions (DMF support files, stability data) can be provided to qualified partners.
Why Choose Us?
1. Direct Manufacturer Pricing
Eliminate intermediary costs. Your procurement budget gains 15-30% efficiency through our factory-direct model.
2. Flexible Order Quantities
Consolidate multiple plant extract orders with lower MOQs per product. This reduces your per-shipment logistics expenses and inventory carrying costs.
3. Regulatory Compliance Expertise
With 20+ years in international markets, we pre-emptively address your regional registration requirements (EU Cosmetics Regulation, FDA GRAS notifications).
4. Stable Supply Chain
Our warehouse stocking system ensures year-round availability, protecting you from seasonal raw material shortages that disrupt production schedules.
Quality Control
We employ multi-stage quality verification to ensure your Madecassic Acid Powder meets international pharmaceutical standards:
Raw Material Screening: Botanical authentication via DNA barcoding and microscopic analysis
HPLC Quantification: Verified potency assurance (10%-95%) with RSD <2%
Heavy Metal Testing: Pb, As, Cd, Hg levels comply with USP <232>/<233> standards
Microbial Limits: Total plate count <1000 CFU/g; Yeast & mold <100 CFU/g
Residual Solvents: Ethanol and acetone levels per ICH Q3C guidelines
Every batch includes a Certificate of Analysis (CoA) with third-party validation available upon request.
Payment & Shipment
Payment Terms: T/T, L/C, Western Union, Paypal (adjustable according to the order quantity)
Shipping Partners: Our shipping partners include FedEx, DHL, EMS, UPS, TNT and specialised pharmaceutical goods forwarders.
Our logistics staff helps customers in Europe and the United States with no import expertise to pass customs. We can ship straight to your warehouse door, saving you the time and complication of clearance.
Packaging & Transportation
Standard Packaging 1kg/Aluminum foil bag 25kg/Fiber drum with double-layer PE bag inside
Custom Options: Aseptic packaging for medicinal applications
Storage Conditions: Store in an airtight container, light and moisture free at 2-8°C
Shelf Life : 24 months under stated parameters
Temperature-controlled transportation keeps your product potent throughout transit, even in harsh regions.
Exhibitions
We showcase innovations at:
- Vitafoods Europe (Geneva) – Annual participation since 2015
- SupplySide West (Las Vegas) – Demonstrating latest extraction technologies
- in-cosmetics Global – Featuring application case studies in skin repair
Visit our booth to discuss customized specifications or schedule factory audits.
After-sales Service
Our commitment extends beyond delivery:
- Technical Support: Formulation guidance from our 30-member R&D team
- Sample Retention: Reference samples stored for 3 years for traceability
- Complaint Resolution: 48-hour response time with investigation reports
- Reformulation Assistance: If batch performance varies, we provide complimentary replacement or formulation adjustment consultation
FAQ
Q: What is the typical purity range you can provide?
A: We provide goods in 10% to 95% purity (tested by HPLC). And custom specs above 98% are possible for pharmaceutical synthesis applications.
Q: How does Madecassic Acid differ from Asiaticoside?
A: Both are actives from Centella. Madecassic Acid is the superiorly lipid soluble aglycone form for enhanced skin penetration in anhydrous preparations. In aqueous systems, Asiaticoside is the recommended glycoside.
Q:Do you have stability data for formulation development?
A: Yes. Accelerated stability tests (40ºC/75% RH) and photostability data (ICH Q1B) are available to help you meet your product development schedule.
Q: Are there any organic or wild-crafted choices?
A: At the moment we grow our Centella asiatica under GAP standards. We are going to be organic, and we expect to have that available in Q3 of 2025.
Q: How long does it take to produce bulk orders?
A: Standard orders ship in 7-10 business days. Custom specs or purity >90% are 15-20 days for production/QC confirmation.
Q: Are samples available for testing?
A: Yes. We provide 20-50g samples for qualified formulators and purchasing managers. Courier costs are prepaid by the recipient or deducted from your first order.
Contact Us
Ready to elevate your formulation with pharmaceutical-grade Madecassic Acid Powder? Reach us at sales@jayuanbio.com and sales1@jayuanbio.com for quotations, CoA samples, or factory audit arrangements.
